β榄香烯；兔；VX2肾癌；辐射增敏药；细胞凋亡_

β榄香烯对兔VX2肾癌放疗增敏作用中Caspase3及Bcl2的表达

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β榄香烯；兔；VX2肾癌；辐射增敏药；细胞凋亡,,β榄香烯；兔；VX2肾癌；辐射增敏药；细胞凋亡,0引言,1材料和

     Expressions of Caspase3 and Bcl2 in radiosensitization of βelemene on rabbit VX2 renal carcinoma

    SHE JunJun, WANG ZiMing, CHE XiangMing, CHONG Tie, WANG YaLi

    Department of Urology, Department of Oncology, Second Affiliated Hospital, Xian Jiaotong University, Xian 710004, China, Department of General Surgery, First Affiliated Hospital, Xian 710061, China

    【Abstract】 AIM: To investigate whether lowdosage βelemene can enhance the effect of irradiation on rabbit VX2 renal carcinoma and to observe the expression changes of Caspase3 and Bcl2 during the process. METHODS: Experimental rabbits with VX2 renal carcinoma were divided into 3 groups: control, radiation and radiation+ βelemene. 10 mg/kg βelemene emulsion was infused through the renal artery. The change of tumors volume was measured dynamically by Bultrasound. Then the tumor tissues were studied comparatively with light microscope and transmission electron microscope. The expressions of Caspase3 and Bcl2 were dctected by immunohistochemistry. RESULTS: The tumor's volume of radiosensitivity group observed by B ultrasound was restrained obviously and its Averagewaitingtime was prolonged from(20.9±1.30) d to(23.0±2.13) d(P<0.05). Different apoptosis were observed under transmission electron microscopy. The expressions of Caspase3 and Bcl2 showed gradient among these groups. CONCLUSION: Lowdosage βelemene could enhance the radiosensitivity of rabbit VX2 renal carcinoma model and promoted the apoptosis through Caspase3 pathway. It could upregulate Bax and downregulate Bcl2 protein expressions. ......

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