[摘要]目的 比较西酞普兰与阿米替林治疗老年抑郁症的疗效及不良反应。方法 将72例符合CCMD-3诊断标准的老年抑郁症病人随机分为两组，分别采用西酞普兰和阿米替林治疗8周，采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和不良反应。结果 西酞普兰组疗效优于阿米替林组( uc =1.81，P <0.05)，副作用轻于阿米替林组( t=5.01～15.91，P <0.05、0.01)。结论 西酞普兰是一种既有效又安全的新型抗抑郁药，适用于老年抑郁症的治疗。

    [关键词] 西酞普兰;阿米替林;抑郁症;老年人;治疗结果

    COMPARISON BETWEEN THE THERAPEUTIC EFFECTS OF CITALOPRAM AND AMITRIPTYLINE FOR SENILE DEPRESSION

    WANG DONG-MING ， CUI WEI-ZHEN， SUN BO

    (The Mental Health Center of Qingdao， Qingdao 266034， China)

    [ABSTRACT]ObjectiveTo compare the therapeutic effects and side effects of citalopram and amitriptyline in the treatment of senile depression. MethodsSeventy-two patients confirmed to CCMD-3 standards were randomized evenly to citalopram group and amitriptyline group. They were given citalopram or amitriptyline for eight weeks. The therapeutic effects and side effects were evaluated by HAMD ......