[摘要]目的 对锡类贴片制备工艺的配方比例、稳定性、黏附性及释放度进行研究，为制备工艺提供依据。方法 通过测定贴片稳定性、黏附性和释放性能确定贴片的配比和工艺。结果 最佳配比CMC-Na∶L-HPC∶锡类散=1∶1.1∶0.94，此配比使贴片具有较好的药物黏附性能且性质稳定，并具有缓释作用。结论 按此最佳配比制备的贴片既有良好的黏附作用又可定位释放，延长了药物与病灶部位的作用时间，提高了疗效。

    [关键词] 锡类贴片;药物稳定性;药物释放系统

    THE PRODUCTION TECHNIQUE， STABILITY， ADHESIVITY AND RELEASE PROPERTY OF XILEI PICKING

    DING YUE-FANG， ZHAN YI， ZHANG HENG， et al

    (Department of Pharmacy， Qingdao Hiser Medical Group， Qingdao 266033，China)

    [ABSTRACT]ObjectiveTo provide the theoretic basis for production technique of Xilei picking by studying its recipe， sta-bility， adhesivity and release property. MethodsThe recipe and producing technique of the picking were determined by detec-ting its stability， adhesivity and release property. ResultsThe proportion of CMC-Na∶L-HPC∶Xilei powder =1∶1.1∶0.94 had best adhesivity ......