β环糊精；包结物；化合物RS_

βCDRS包结物的制备及表征天津市应用基础研究重点项目(043802511)

http://www.100md.com 《咸宁学院学报(医学版)》 2006年第5期

β环糊精；包结物；化合物RS,,β环糊精；包结物；化合物RS,1材料与方法,2结果,3结论,参考文献：

     摘要：目的制备17α，21二羟基孕甾4烯3,20二酮(RS)和β环糊精(βCD)包结物。方法 RS和βCD经超声波处理40 min，再于28 ℃，120 r/min振荡处理12 h，形成包结物。结果 βCDRS包结物的紫外吸收特征与化合物RS一致。显微观察表明βCD为斜方片状晶体，化合物RS为针状晶体，βCDRS包结物呈不定形，证实了βCDRS包结物的形成。FTIR、DSC分析进一步证实了βCDRS包结物的形成。结论此法是制备βCDRS包结物的有效方法。

    关键词：β环糊精；包结物；化合物RS

    Preparation and Characterization of βCDRS Inclution Complex

    CHEN Xiao, LI Xiuxiu, WANG Min

    (Tianjin University of Science and Technology,Tianjin 300222,China)

    ABSTRACT:Objective To prepare the inclusion complex of RS withβCD. Methods The inclusion complex was prepared at 28℃ with 40min ultrasonics and 12h shaking. Results The ultraviolet spectra of RS is consistent with RS inclusion complex. Microscopic examination shows that βCD is orthorhombic crystal, and compound RS is needlelike crystal and βCDRS inclusion complex is irregular that proves the formation of βCDRS inclusion complex. Using FTIR and DSC analysis could also substantiate the formation of βCDRS inclusion complex.Conclusion It is a convenient and feasible method to prepare βCDRS. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/01/16/34/11/84.htm

您现在查看是摘要页，全文长 7144 字符。