摘要:目的 探讨乙型肝炎病毒(HBV)基因型与拉米夫定治疗疗效的关系及其机理。 方法 收集拉米夫定治疗的51例慢性乙型肝炎患者的临床资料，分析HBV基因型与拉米夫定治疗疗效的关系。 结果 HBV基因型B型对拉米夫定的应答率为45.4%(10/22)，C基因型的应答率为20.7%(6/29)，两组应答率差异有显著性(P<0.05);B基因型的HBeAg的血清转换率为31.8%(7/22)，C基因型为13.8%(4/29)，经统计学处理差异有显著性(P<0.05)。 结论 拉米夫定治疗慢性乙型肝炎患者，B基因型疗效较C基因型好，HBV基因型可能是预测拉米夫定治疗效果的因素之一。

    关键词:乙型肝炎病毒;基因型;拉米夫定

    Relationship between the genotypes of hepatitis B virus and the response to lamivudine therapy.

    YANG Hai-hong，ZENG Wen-ting，WEI Jian-jun.

    (Department of Infection Diseases;the First Affiliated Hospital of Guangzhou Medical College，Guangzhou510120，Guangdong，P.R.China)

    Abstract:Objective To study the relationship between the genotypes of hepatitis B virus and the response to lamivudine thera-py. Methods The clinical data of51patients with chronic hepatitis B(CHB)treated with lamivudine were collected.The rela-tionship between the genotypes of hepatitis B virus and response to lamivudine therapy was analyzed. Results The rate of antiviral response to lamivudine therapy in patients with genotype B virus infection and genotype C virus infection was45.4%(10/22)and20.7%(6/29)respectively.There was significant difference between the two groups(P<0.05).The seroconversion rate of serum HBeAg in patients with genotype B virus infection was significantly higher than those with genotype C infection(31.8%vs13.8% ......