摘要:目的 观察急性髓细胞性白血病(AML)患者化疗前后血中LDH、IL-2与IL-12的水平变化，探讨各指标的临床意义。 方法 初次治疗的白血病患者共36例，经DA方案化疗两个疗程后有不同程度缓解26例，测定治疗前后血中LDH、IL-2与IL-12水平，并与对照组相比较。未缓解10例只比较治疗前后的LDH结果。 结果 缓解组26例，其中LDH治疗前为454.3±113.6，显著高于对照组96.7±28.6，治疗后LDH为211.5±57.6显著降低;IL-2治疗前为13.8±11.4，显著低于对照组33.6±8.4，治疗后IL-2为35.4±15.3显著升高;IL-12治疗前为19.3±6.5，显著低于对照组31.3±13.8，治疗后为40.2±17.3显著升高。未缓解10例治疗前LDH为653.2±326.4，治疗后为512.3±286.7，差异无显著性。 结论 白血病患者化疗后骨髓示缓解者其LDH较化疗前显著降低，IL-2与IL-12均较化疗前显著升高。

    关键词:AML;乳酸脱氢酶;白细胞介素-2;白细胞介素-12

    The variation of LDH，IL-2and IL-12levels in acute myelocytic leukemia cases before and after treatment.

    PANG Wei-jun，ZHANG Yu-ming.

    (Affiliated Hospital of Guangdong Medical College，Zhanjiang524001，Guangdong，P.R.China)

    Abstract:Objective To observe the changes of levels of LDH，IL-2and IL-12in the blood of acute myelemia(AML)pa-tients before and after treatment and explore the clinical significance of other indexes. Methods Thirty-six leukemia patients were initially treated and the relieve of carious degree was achieved in26two months after chemical treatment ......