【摘 要】 目的 探讨不同剂量基因重组人骨形成蛋白(rhBMP-2)对兔下颌骨牵引区新骨生成及内皮型一氧化氮合酶(eNOS)表达的影响。 方法 日本大耳白兔45只，随机分为3组，每组15只，建立动物模型，通过组织学观察和免疫组化方法检测新骨形成及其表达的eNOS。 结果 同一时间点新骨随rhBMP-2的增多而变成熟。eNOS的峰值rhBMP-2组较空白组前提;在同一时间点eNOS随rhBMP-2的增多而表达增强，在28d时各组表达的eNOS无明显差异。 结论 rhBMP-2在成骨早期以剂量依赖方式促进兔下颌牵引区eNOS的表达和新骨形成。

    【关键词】 牵引成骨;基因重组人骨形成蛋白2;内皮型一氧化氮合酶

    Effects of rhBMP┐2on mandibular distraction osteogenesis and the expression of eNOS in the new bone MA Yan，WANG Zhi-ying，LI Xin-wei.(Department of Oral Surgery，The Second Affiliated Hospital of Jinzhou Medical Col-lege，Liaoning121001，China)

    【Abstract】 Objective To investigate the effects of different concertrations of rhBMP-2on mandibular distraction osteogenesis and the expression of eNOS in the different consolidation period of distraction osteogenesis.Methods The distraction osteogenesis model was set up.And then the specimens were examined histologically and immunohis┐tochemically.Results Both mandibles of each animal were lengthened successfully.In the same period ......