骨质疏松性骨折;_骨保护素表达;骨折愈合;_成骨细胞

骨质疏松性骨折愈合过程中骨保护素的表达

http://www.100md.com 《咸宁学院学报(医学版)》 2006年第4期

骨质疏松性骨折;,骨保护素表达;骨折愈合;,成骨细胞,,骨质疏松性骨折;,骨保护素表达;骨折愈合;,成骨细胞,1材料和方法,2结果,3讨论,参考文献：

     摘要：目的观察骨质疏松性骨折愈合不同阶段中骨保护素(OPG)的表达，探讨OPG在该过程中的作用。方法 8月龄雌性大鼠40只，随机分为卵巢切除组和假切组,相同条件喂养3个月后造骨折模型，分别于术后第10d、第20d、第30d、第40d取骨痂，通过RTPCR及ELISA检测骨质疏松性骨折及正常骨折愈合过程中骨痂OPG表达。结果 OPG在骨质疏松性骨折愈合过程表达较其在正常组表达明显减弱(P<0.05)。结论 OPG是影响骨质疏松性骨折愈合的关键因子。

    关键词：骨质疏松性骨折; 骨保护素表达;骨折愈合; 成骨细胞

    The Expression of Osteoprotegerin in the Healing Process of Osteoporotic Fracture

    ZHANG Xiaoming,CHEN Sunyu,XIAO Deming,et al

    (Shenzhen People’s Hospital,Shenzhen Guangdong 518020 ,China)

    ABSTRACT:Objective To investigate the expression and function of osteoprotegerin(OPG) in the healing process of osteoporotic fracture. Methods Eight months old SD rats were randomly divided into ovariectomized group (Ovx) and sham operation group (Sham). After 3 months fed in the same way, all animals were maked fracturing. Using RTPCR and ELISA to detect OPG and to compare data between two groups at different time. Results The expression of OPG in the healing process of osteoporotic fracture is weak. Compared with the Sham group,the expression level of OPG in Ovx group was significantly reduced (P<0.05).Conclusion The OPG is an critical cytokine for the healing of osteoprotic fracture. ......

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