黄芪注射液；阿霉素；肌酸激酶同工酶；中毒性心肌炎_

黄芪注射液对小鼠中毒性心肌炎的保护作用

http://www.100md.com 《咸宁学院学报(医学版)》 2006年第4期

黄芪注射液；阿霉素；肌酸激酶同工酶；中毒性心肌炎,,黄芪注射液；阿霉素；肌酸激酶同工酶；中毒性心肌炎,1材料与方法,2结果,3讨论

     摘要：目的研究黄芪注射液(AI)对中毒性心肌炎的保护作用。方法建立小鼠阿霉素(ADR)中毒性心肌炎模型，记录实验结束时小鼠存活率和心电图改变，测定血清肌酸激酶同工酶(CKMB)、肌酸激酶(CK)和谷草转氨酶(GOT)活力，同时进行形态学观察。结果 ADR可致小鼠存活率明显降低，心电图出现特异性改变，同时ADR使小鼠体重明显降低(P<0.01)，ADR还可使血清CKMB、CK和GOT活力显著升高(P<0.01)。AI能逆转ADR所致的上述改变，表现为提高小鼠存活率和体重，剂量依赖性降低血清CKMB、CK和GOT活力。病理检查发现AI对ADR中毒性心肌炎有很好的保护作用。结论 AI能拮抗ADR所致的小鼠中毒性心肌炎，其作用机制可能与抗心肌脂质过氧化有关。

    关键词：黄芪注射液；阿霉素；肌酸激酶同工酶；中毒性心肌炎

    Protective Effect of Astragalus Injection on Adriamycininduced Toxic Myocarditis in Mice

    LI Jia

    (Department of Pathophysioligy,Xianning College, Xianning Hubei 437100,China)

    ABSTRACT：Objective To study the protective effects of Astragalus injection (AI) on adriamycin(ADR)induced toxic myocarditis in mice. Methods ADR was injected intraperitoneally to induce myocardium injury model in mice. The survival rate and the ECG changes were observed. The activities of creatine kinase isoenzymes (CKMB),creatine kinase (CK) and glutamic oxaloacetic transaminase (GOT) were measured. Results ADR induced severe myocardial damages with the increasing activities of CKMB,CK and GOT (P<0.01) ......

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