摘要:目的 观察干扰素联合大剂量胸腺肽治疗慢性乙型肝炎抗HBV复制的临床疗效。 方法 将77例HBeAg阳性、HBV-DNA阳性，随机分为治疗组54例使用干扰素联合胸腺肽治疗，对照组23例除不用胸腺肽外，干扰素用法及疗程同治疗组。 结果 观察组两药联合应用后，HBeAg和HBV-DNA阴转率分别达64.8%和68.5%;对照组上述指标阴转率分别为39.1%和43.5%，两组间HBeAg和HBV-DNA各指标间比较均有差异显著性(P<0.05)。疗程中未见明显毒副反应。 结论 干扰素联合大剂量胸腺肽能提高抗乙肝病毒复制的疗效。

    关键词:慢性乙型肝炎;干扰素;胸腺肽;联合治疗

    Clinical observation on the results in treatment of chronic hepatitis B infections with interferon and thymosin.

    LIN Lin，HUANG Zhi.

    (Donghu Hospital of Shenzhen City，Shenzhen518020，Guangdong，P.R.China)

    Abstract:Objective To observe the clinical anti-HBV-replication effect of IFN-a lb combined with large dose of thy-mopeptide on patients with chronic hepatitis B. Methods 77patients with chronic hepatitis B whose HBeAg and HBV-DNAwere positive were enrolled in this research and divided into two groups randomly:treatment group and control group.23patients in control group were treated in the same procedure except without using thymopeptide. Results In treatment group ......