摘要:目的 观察双氢青蒿素哌喹片对云南省恶性疟的疗效和安全性。 方法 在云南边境抗药性恶性疟流行区选择恶性疟患者69例，用双氢青蒿素哌喹片2d4次疗法治疗并追踪观察28d。 结果 治愈率为100%，平均退热时间(34.99±16.51)h;平均无性体原虫转阴时间(33.14±11.91)h;配子体转阴率为95.46%，临床及实验室检查均未见明显不良反应。 结论 双氢青蒿素哌喹片2d4次疗法治疗云南恶性疟具有高效、速效、低毒、疗程短、服药依从性高、配子体转阴率高等优点。

    关键词:双氢青蒿素哌喹片;2d4次疗法;恶性疟;云南省

    Clinical study on the efficacy of dihyroartemisinin and piperaquine in treatment of multi-drug resistant Plasmodium falciparum.

    SUN Xiao-dong，ZHANG Zai-xing，LIUDe-quan，et al.

    (Yunnan Provincial Institute of Parasitic Diseases，Simao665000，Yunnan，P.R.China)

    Abstract:Objective To observe the effect and safety of Dihydroartemisinin Piperaquine Phosphate Tablets(DPPT)in treatment of falciparum malaria in Yunnan Province. Methods 69falciparum malaria cases，who came from the endemic areas of drug resis-tant falciparum malaria on the border of Yunnan Province ......