摘要:目的 了解高血压所致的冠心病(简称高冠心病)患者治疗前后血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)的水平变化，探讨其临床意义及其与冠脉损伤的相互关系。 方法 108例高血压冠心病患者均行冠状动脉造影术，并以放射免疫法测定浆肾素、血管紧张素和醛固酮含量。 结果 高冠心病组血浆PRA、AngⅡ和ALD水平分别为2.53±1.85(μg/L/h)、41.30±11.80(ng/L)、150.00±85.03(ng/L)，较对照组明显增高;高冠心病组轻型、中型、重型三组各组血浆PRA、AngⅡ和ALD水平呈逐步升高态势，轻型<中型<重型，组间相互比较均有显著性和非常显著性差异。高冠心病组治疗后血浆PRA、AngⅡ和ALD含量分别为(1.87±2.15)μg/L/h、(37.13±8.80)ng/L和(110.00±62.22)ng/L，与治疗前比较有差异非常显著性(P<0.01)。冠状动脉损害程度越重，血浆PRA、AngⅡ和ALD含量越高。 结论 降低血浆肾素、血管紧张素和醛固酮水平，可直接调控血压，使血压维持在一个适当水平，是治疗高冠心病，减少心脏事件发生的关键，同时血浆肾素、血管紧张素、醛固酮水平对预测高冠心病冠脉损害程度及监测疗效具有重要的临床意义。

    关键词:血浆肾素;血管紧张素Ⅱ;醛固酮;冠心病

    Clinical significance and levels of plasma rennin activity，angiotensin II and aldeosterone detected from plasma of hy-pertension and coronary heart disease patients before and after treatment.

    SHI Guang-qing，DAI Zhong-wei，XIANG Gu-liang，et al.

    (Department of Nuclear of the Third Xiangya Hospital of Zhongnan University，Changsha410013，Hunan，P.R.Chi-na)

    Abstract:Objective To observe the clinical significance and levels of plasma rennin activity，angiotensinⅡand aldeosterone detected from plasma of hypertension and coronary heart disease patients and their relation with trauma to coronary artery. Methods 108hypertension and coronary heart disease patients aged48±21years old from outpatient and inpatient departments were sur-veyed including75males and33females.All the patients examined with coronary tomography by standard Judkins. Results The levels of plasma rennin activity ......