新福菌素联合卡铂、依托泊苷治疗老年非小细胞肺癌临床疗效观察
老年；非小细胞肺癌；化疗；新福菌素；卡铂；依托泊苷,,老年；非小细胞肺癌；化疗；新福菌素；卡铂；依托泊苷,1资料和方法,2结果,3讨论
【摘要】 目的：评价国产新福菌素对老年非小细胞肺癌(NSCLC)的疗效和不良反应。方法：选取老年NSCLC病例81例，随机分治疗组43例给予新福菌素6μg/kg(第1~4d)，卡铂(CBP)300mg/m2(第1d)，依托泊苷(VP16)100 mg(第1~4或5d)静脉滴注；对照组38例单纯使用CBP和VP16，剂量和方法同治疗组，21~28d为一个疗程，2~3个疗程评价疗效，随访缓解期和生存期。结果：治疗组有效率为5349%，对照组有效率为3158%，差异有显著性(P<005)；中位缓解期分别为6和45个月，中位生存期分别为9和7个月，一年生存率分别为3953%(17/43)和2632%(10/38)。结论：新福菌素联合CBP、VP16治疗老年NSCLC有较好的临床疗效及应用价值。【关键词】 老年；非小细胞肺癌；化疗；新福菌素；卡铂；依托泊苷
Clinical Study on Sinoactionomycin Combining Card Platinum and VP16 in Treating Elderly Non small Cell Lung Cancer
ZHAO Jianqing,XING Liqiang,QIAN Haihong， et al
Respiratory Department, The First Affiliated Hospital,Hebei North University,Zhangjiakou,075000,Hebei,China; Hebei North University, Zhangjiakou, 075000,Hebei,China)
【ABSTRACT】 Objective:To investigate the curative effects and sideeffect of domestic drugSinoactionomycin in treating elderly nonsmall cell lung cancer (NSCLC).Methods: 81 cases with elderly NSCLC were divided into two groups randomly,43 cases in the treatment group were administrated with Sinoactionomycin 6g/kg (1~4 day) combining card platinum (CBP) 300mg/m2 (1st day), glucoside (VP16) 100 mg (1~4 or 5days) intravenously.38 cases in the control group were only treated with CBP and vp16 and the dosage were same with that of treatment group.21~28 days were taken as a treatment cycle and the curative effects were studied after 2~3 cycles.The relievable and survival periods were investigated as well.Results: The effectiveness for treatment troup is 5349%, effectiveness for control group is 3158%, the difference has the significance (P<005); The central relievable period is 6 and 45 months respectively, and the central survival period is 9 and 7 months respectively,on year survival rate respectively is 3953% (17,/43) and 2632% (10,/38). Conclusion: Sinoactionomycin combining CBP,and VP16 has good clinical curative effect in treating elderly NSCLC and has the good clinical practice value. ......
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