【摘 要】 目的 探讨胰岛素强化治疗对初诊2型糖尿病患者血管内皮功能的影响。 方法 选择初诊2型糖尿病患者43例，应用胰岛素泵短期强化治疗，观察治疗前后血管内皮功能及体脂、血压、血脂、血糖、胰岛素抵抗指数(HOMA-IR)的变化。 结果 初诊2型糖尿病患者已存在血管内皮依赖性舒张(EDD)功能受损，并伴有各项代谢指标异常。经胰岛素强化治疗使血糖控制达标后，EDD由5.48±2.24增加为10.36±3.73(P<0.01)，血脂及HOMA-IR显著降低(分别为P<0.05和P<0.01)。 结论 初诊2型糖尿病早期胰岛素强化治疗不仅可有效治疗糖脂代谢紊乱，并可显著改善血管内皮依赖性舒张功能。

    【关键词】 2型糖尿病;胰岛素;血管内皮功能

    Effect of Intensive Insulin Therapy on Vascular Endothelial Function in Newly Diagnosed Type2Diabetes Patients ZHU Lvyun，YANG Shaoling，TIAN Qingbo，et al.Department of Endocrinology，Bethune International Peace Hospital of PLA，Shijiazhuang 050082，China

    【Abstract】 Objective To discuss the effect of intensive insulin therapy on endothelial function in newly diagnosed type2diabetes patients.Methods Forty-three newly diagnosed type2diabetes patients were treated with intensive insulin therapy for two weeks.Endothelial function，body fat，blood pressure，lipid profile，blood glucose，insulin resistance index(HOMA-IR)were compared before and after treatment.Results The pa-tients with newly diagnosed type2diabetes had obvious endothelial-dependent dilation(EDD)dysfunction and abnormal metabolic parameters.After the treatment ......