[摘要]目的 了解来氟米特(LEF)治疗Ⅳ型狼疮性肾炎的临床效果、安全性和副作用。方法 10例活动性狼疮性肾炎(LN)病人，肾活检显示为活动性Ⅳ型狼疮性肾炎，治疗前尿蛋白>2 g/24 h，有明显血尿或管型尿，应用LEF联合糖皮质激素治疗6个月。用药期间监测血常规、尿常规、24 h尿蛋白定量、肝肾功能、抗核抗体及抗双链抗体滴度、红细胞沉降率和补体C3 等，6个月后行疗效和安全性的评价。结果 共有6例(60%)缓解，3例部分缓解，1例无效。2例出现胃肠道反应，1例发生过敏反应，1例发生一过性白细胞下降，未见肝功能异常。结论LEF联合糖皮 质激素治疗能有效控制狼疮活动且副作用轻，耐受性好。

    [关键词] 狼疮肾炎;来氟米特;糖皮质激素类;治疗结果

    EFFECTS OF LEFLUNOMIDE COMBINED WITH GLUCOCORTICOSTEROIDS ON PATIENTS WITH DIFFUSE PROLIFERATIVE LUPUS NEPHRITIS

    CAO CAI-XIA， WANG LING， LIU LI-QIU

    (Qingdao Sanatorium of Shandong Province， Qingdao 266003， China)

    [ABSTRACT]ObjectiveTo evaluate the clinical efficacy， safety and adverse effects of Leflunomide (LEF) in the treatment of patients with diffuse proliferative lupus nephritis (type Ⅳ). MethodsTen patients with lupus nephritis (LN) were confirmed by renal biopsy as having type-Ⅳ LN. They had obvious hematuria or cylinderuria ......