[摘要]目的 探讨二甲苯对正常人外周血淋巴细胞DNA的损伤作用。方法 采用染色体分析技术，对体外培养的外周血淋巴细胞姊妹染色单体交换(SCE)频率进行观察。结果 3.0、6.0 mmol/L二甲苯组淋巴细胞中的SCE计数平均值分别为7.533±0.234、10.933±0.325，与对照组(2.800±0.242)比较，差异具有极显著性(t=14.084、20.085，P <0.001)。结论 二甲苯对正常人外周血淋巴细胞DNA有显著损伤作用。

    [关键词] 二甲苯类;淋巴细胞;姐妹染色单体交换

    EFFECTS OF XYLENE ON SCE FREQUENCIES IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES

    LIU JIN-CHENG， SU AI

    (Department of Biology， Qingdao University Medical College， Qingdao 266021， China)

    [ABSTRACT]ObjectiveTo investigate the damage of xylene on DNA of human peripheral blood lymphocytes. Methods Chromosome analysis technique was used to study sister chromatid exchange (SCE) frequencies of in-vitro-culture blood lympho-cyte. ResultsThe frequencies of SCE in xylene groups (3.0 mmol/ L ......