纤维化胰腺组织中TGF-β1、Smad3、Smad7的表达及意义
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马松林, 赵 秋, 龚 勇, 王 渝, 杨 芳
转化生长因子b1;Smad3;Smad7;胰腺纤维化马松林,赵秋,龚勇,王渝,杨芳.纤维化胰腺组织中TGF-b1、Smad3、Smad7的表达及意义. 世界华人消化杂志2007;15(2)185-188,马松林,赵秋,龚勇
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马松林, 赵秋, 龚勇, 王渝, 杨芳, 华中科技大学同济医学院附属同济医院消化内科 湖北省武汉市 430030
通讯作者: 赵秋, 430030, 湖北省武汉市汉口解放大道1095号, 华中科技大学同济医学院附属同济医院消化内科.
tongji46@sina.com
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收稿日期: 2006-10-30 接受日期: 2006-11-24
Expression of transforming growth factor-β1, Smad3 and Smad7 and their significances in pancreatic fibrosis
Song-Lin Ma, Qiu Zhao, Yong Gong, Yu Wang, Fang Yang
Song-Lin Ma, Qiu Zhao, Yong Gong, Yu Wang, Fang Yang, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Qiu Zhao, Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. tongji461@sina.com
Received: 2006-10-30 Accepted: 2006-11-24
AbstractAIM: To investigate the expression of trans-forming growth factor-b1 (TGF-b1), Smad3 and Smad7 protein in human pancreatic fibrosis as well as their significances.
METHODS: SP immunohistochemical method was used to determine the expression of TGF-b1, Smad3 and Smad7 protein in 34 cases of pancreatic fibrosis tissues and 15 cases of normal pancreatic tissues.
RESULTS: The expression of TGF-b1 and Smad3 were significantly higher in pancreatic fibrosis tissues than those in normal pancreatic tissues (TGF-b1: 79.4% vs 6.7%, P < 0.01; Smad3: 64.7% vs 20.0%, P < 0.01), while the expression of Smad7 was marked lower in pancreatic fibrosis tissues were than that in normal pancreatic tissues (26.5% vs 73.3%, P < 0.01). The expression of TGF-b1 was positively correlated with that of Smad3 (r = 0.385, P < 0.05), but reversely correlated with that of Smad7 (r = -0.519,P<0.01).
CONCLUSION: TGF-b1, Smad3 and Smad7 may play distinct intermediate roles in the process of pancreatic fibrosis ......
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