硝苯地平聚乙二醇(PEG)固体分散体的制备
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任君刚，邹梅娟，王 悦，程 刚
(沈阳药科大学 药学院，辽宁 沈阳110016)
摘 要： 目的 制备硝苯地平的固体分散体，以提高硝苯地平的体外溶出度。方法 分别以PEG 2000、PEG 4000和PEG 6000为载体，采用溶剂-熔融法制备硝苯地平固体分散体。结果 当药物与载体比例一定时，硝苯地平的溶出速率随载体材料相对分子质量的增加而增大；载体材料一定时，硝苯地平溶出速率随药物-载体比例的增加而减小；与原料药相比，制备的PEG固体分散体能明显加快药物的溶出。结论 硝苯地平PEG固体分散体能加快药物的体外溶出速率。
关键词：药剂学；溶剂-熔融法；硝苯地平；固体分散体
中图分类号：R94 文献标识码：A
contents
Preparation of nifedipine-PEG solid dispersions
REN Jun-gang , ZOU Mei-juan , WANG Yue , CHENG Gang
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,China)
Abstract: Objective To prepare a nifedipine solid dispersion with PEG of different molecular weight as carrier for enhancing the in vitro drug dissolution. Method Solvent-melting method was used to prepare solid dispersion with PEG2000, PEG4000 or PEG6000 as the carrier. Results The higher the molecular weight of PEG was, the higher the dissolution rate of nifedipine when the ratio of drug/carrier was decided, and with the increasing of the ratio of drug-carrier the dissolution of drug was degraded. The prepared solid dispersions could improve the dissolution of the drug apparently compared with the original crystals of nifedipine. Conclusion The nifedipine-PEG solid dispersion could accelerate the in vitro drug dissolution.
Key words: pharmaceutics; solvent-melting method; nifedipine; solid dispersions
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