盐酸阿比朵尔缓释微丸的制备与体外释药评价
http://www.100md.com
| 第1页 |
| 第7页 |
参见附件(121KB，7页)。
代 奕，李三鸣，余李敏，殷 丹，姚慧敏
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要：目的 制备盐酸阿比朵尔缓释微丸并考察其体外释放影响因素。方法 正交设计优化含药丸芯处方，单因素实验考察包衣液中增塑剂、抗粘剂、致孔剂及包衣增重对药物释放的影响。结果 以MCC和乳糖为辅料制备丸芯，以Eudragitâ RL30D为包衣材料，包衣液质量分数为20%，TEC质量分数为15%，滑石粉质量分数为50%，乳糖质量分数为5%，包衣增重为20%时可以制得释药较好的缓释微丸。结论 盐酸阿比朵尔缓释微丸体外释药具有明显的缓释特性，释药规律符合一级释药模型。
关键词：药剂学；缓释微丸；流化床悬浮包衣；盐酸阿比朵尔；体外释药
中图分类号：R94 文献标识码：A contents
Preparation of arbidol hydrochloride sustained-release pellets and evaluation on the release behaviour
DAI Yi，LI San-ming，YU Li-min，YIN Dan，YAO Hui-min
(School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China)
Abstract: Objective To prepare arbidol hydrochloride sustained-release pellets and investigate the mechanism of release. Methods The orthogonal design was used to optimize the formulation of the core of pellets. Single-factor method was used to investigate the influence of contenting of plasticizer, anti-adherent, poremaking agent，coating levels on the release of the pellets. Results The core of pellets were prepared by MCC and lactose, with Eudragitâ RL30D as coating materials. The gained weight of the coated pellets was 20%. Conclusions The coated pellets has a remarkable sustained-release property, the drug release profile in vitro follows first order kinetics.
Key words: pharmaceutics; sustained-release pellets; fluid bed coating; arbidol hydrochloride; release in vitro；
您现在查看是摘要介绍页，详见PDF附件(121KB，7页)。