流化床包衣法制备盐酸普萘洛尔药物树脂缓释微囊
http://www.100md.com
| 第1页 |
| 第5页 |
参见附件(215KB，7页)。
孙西洋, 刘宏飞, 曹心珂, 潘卫三
(沈阳药科大学 药学院, 辽宁沈阳 110016)
摘要: 目的 采用流化床包衣法制备缓释药物树脂微囊,并考察其释放特性。方法 采用底喷式空气悬浮包衣法，以药物树脂复合物为囊心, SureleaseÒ 水分散体为包衣材料, 通过对药物释放特性的考察，确定优化的最终包衣工艺及用量。结果 在流化风量 35 m3·h-1, 恒流泵流速 3 mL·min-1, 包衣温度60 ℃的工艺条件下，包衣增质量为10 %、滑石粉用量为8 %时，药物树脂微囊有很好的缓释特征。结论 流化床包衣法制备微囊,工艺稳定、可连续操作。
关键词：药剂学;缓释微囊 ;流化床包衣法; SureleaseÒ 水分散体;盐酸普萘洛尔药物树脂复合物
中图分类号：R94 文献标识码： A contents
Preparation of microcapsules of propranolol hydrochloride-resinates by air-suspention coating process
SUN Xi-yang, LIU Hong-fei, CAO Xin-ke, PAN Wei-san
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To prepare microcapsules of propranolol hydrochloride-resinates by air-suspention coationg process and study its drug release . Methods With SureleaseÒ aqueous dispersions as coating material and the drug-resinates as capsule cores, the microcapsules of PNH-resinates were prepared. Through investigation of the drug release, the final formulation and procedure were defined. Results When air flow rate was 35 m3·h-1, spray rate was 3 mL·min-1, inlet temprature was 60℃ and the weight of coating was 10% and the dosage of talc powder was 8%, microcapsules of propranolol hydrochloride-resinates was able to maintain a sustained release in vitro. Conclusion The air-suspention coating process is simple and reliable.
Key words: pharmaceutics; sustained-release microcapsule; fluidized bed coating; SureleaseÒ aqueous dispersion; propranolol hydrochloride-resinates
您现在查看是摘要介绍页，详见PDF附件(215KB，7页)。