匹多莫德注射液在家兔体内的药物动力学研究
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孙镭芹 ，杨亚军，闫志强，何仲贵
(沈阳药科大学 药学院 辽宁 沈阳 110016)
摘要：目的 研究匹多莫德注射液的药物动力学。 方法 6只家兔，以100 mg∙kg-1的剂量耳缘静脉注射匹多莫德注射液，给药前及给药后不同时间定时采取血样；以HPLC法测定血浆样品中匹多莫德的浓度，并对该制剂的药物动力学特征进行评价。 结果 家兔静脉注射给予匹多莫德后， 匹多莫德的k为(1.2 ± 0.2)h-1， t1/ 2为(0.6 ± 0.1)h， AUC0-t为(240.4 ± 31.0)mg∙h∙L-1， AUC0-∞为(262.2 ± 32.6)mg∙h∙L-1，V为(1.3 ± 0.8)L，CL为(1.4 ± 0.7)L∙ h-1。结论 该研究可为匹多莫德注射液的临床应用提供一定的科学依据。
关键词：药剂学；药物动力学；HPLC；匹多莫德注射液
中图分类号： R94 文献标识码：A
contents
Pharmacokinetics of pidotimod injection
SUN Lei-qin, YANG Ya-jun, YAN Zhi-qiang, HE Zhong-gui
(School of Pharmcy, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To study on the pharmacokinetics of pidotimod injection. Methods Six rabbits were injected with pidotimod injection at the dose of 100 mg∙kg-1. Plasma samples were drawn before and after injection.Plasma concentrations of pidotimod were determined by HPLC and the pharmacokinetics were evaluated. Results The pharmacokinetic parameters of pidotimod were expressed as following: k was(1.2 ± 0.2 ) h-1, t1/2 was (0.6 ± 0.1) h, AUC0-t was (240.4 ± 31.0 ) mg∙h∙L-1, AUC0-∞ was (262.27 ± 32.6) mg∙h∙L-1 , V was (1.3 ± 0.8) L, CL was (1.4 ± 0.7) L∙ h-1. Conclusion The research can supply scientific basis for the clinical application of pidotimod injection.
Key words: pharmaceutics; pharmacokinetics; HPLC; pidotimod injection
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