C-MYC、突变型P53蛋白在小细胞肺癌中的表达及意义
C-MYC蛋白；P53蛋白；小细胞肺癌；免疫组织化学,,],C-MYC蛋白；P53蛋白；小细胞肺癌；免疫组织化学,1资料与方法,2结果,3
[摘要] 目的 研究C-MYC、突变型P53蛋白在小细胞肺癌(SCLC)中的表达并分析其与SCLC临床病理学特征及预后之间的关系。方法 用免疫组化的方法检测30例原发灶及10例正常肺组织中C-MYC、突变型P53蛋白的表达水平，按阳性表达率进行χ2分析。结果 SCLC中C-MYC、突变型P53蛋白表达显著高于正常肺组织。两者阳性表达都与患者的生存期及SCLC分化程度呈负相关(P<0.05)，与SCLC的淋巴结转移呈正相关(P<0.05)，与患者的年龄、肿瘤大小无关(P>0.05)。C-MYC 蛋白表达与肿瘤p-TNM分期呈正相关(P<0.05)，而突变型P53蛋白表达与肿瘤p-TNM分期无相关性(P>0.05)。结论 SCLC存在C-MYC、突变型P53蛋白过度表达，提示它们在SCLC发生、发展过程中可能起着重要作用。[关键词] C-MYC蛋白；P53蛋白；小细胞肺癌；免疫组织化学
Expression of C-MYC and P53 protein in small cell lung cancer and significance
CHEN Kai，ZHANG Wei,YANG Qing.Department of Colorectal and General Surgery,The People’s Hospital of Dongguan,Guangdong 523018,China
[Abstract] Objective This study observed the expression of C-MYC and mutated P53 protein in SCLC,in order to analyse the relationship between their expression and prognosis of the patients as well as clinicpathological characteristic.Methods The immunohistochemical staining method,strepatavidin-peroxidase(S-P)method was used to detect the C-MYC and mutated P53 protein in 30 cases of SCLC.10 normal lung tissues were contrasted.The positive expression was analyzed with χ2 test.Results The expression level of the C-MYC and mutated P53 in cancer tissues were significantly higher than that in the normal lung tissues.Their expression were negatively correlated with survival time and differentiation degree (P<0.05),positive correlated with lymph nodes metastasis.They were not correlated with age and the size of tumor (P>0.05).There was a positive correlation between C-MYC protein and p-TNM stages of the cancer (P<0.05),but mutated P53 protein was not correlated with p-TNM (P>0.05).Conclusion There are the overexpression of C-MYC and mutated P53 protein in SCLC,which suggests that they may play an important role in the occurrence development of SCLC. ......
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