In vivo cardiac electrophysiological and hemodynamic effects of rhBNP in rabbits

    YAO Wei,YANG Bo, QIAN Jin, WU Gang, CHEN Xuª²Jiang, YU Zhiª²Li

    Department of Cardiovasology, People¬ðs Hospital, Wuhan University, Wuhan 430060, China, Department of Internal Medicine, Central Hospital of Suizhou City, Suizhou 441300, China

    ¡¾Abstract¡¿ AIM: To observe the effects of shortª²term infusion of recombinant human brain natriuretic peptide (rhBNP) on electrophysiologic parameters and hemodynamics in healthy rabbits. METHODS: In 12 healthy rabbits, hemodynamic and electrophysiologic parameters were assessed during infusion of rhBNP at 0.09¦Ìg/(kg¡¤min).With monophasic action potential (MAP) recording technique, MAPs of epiª², midª² and endoª²layers of myocyte were recorded simultaneously by composite plungeª²needle electrode across left ventricular wall. Curve of arterial blood pressure and left intraventricular pressure were recorded through common carotid arterial cannula. RESULTS£º Infusion of rhBNP decreased hemodynamic parameters including SAP, DAP, mean arterial pressure(MAP) and LVEDP, LVSP (P<0.05)£»there were no significant changes in left ventricular pressure [ (¡Àdp/dt)max]; there were no significant changes in electrophysiologic parameters including MAPs of epiª², midª² and endoª² myocardium and surface ECG variable. CONCLUSION: In healthy rabbits, shortª²term infusion of rhBNP can change hemodynamic parameters but has no significant effects on electrophysiologic parameters. ......