大肠癌CD24的表达及其与肿瘤细胞增殖和血管形成的关系
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庄建良, 苏子剑, 潘群雄, 许荣誉, 李明珠
大肠肿瘤;流式细胞术;CD24;核增殖抗原;微血管密度,庄建良,潘群雄,许荣誉,李明珠,苏子剑,庄建良,通讯作者:,ExpressionofCD24anditsrelationshipwithangiogenesisandtumor
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庄建良, 潘群雄, 许荣誉, 李明珠, 福建医科大学附属泉州市第一医院肿瘤外科 福建省泉州市 362000
苏子剑, 福建医科大学2004级硕士研究生 福建省福州市 350004
庄建良, 主任医师, 教授, 硕士研究生导师, 主要从事肿瘤的侵袭转移方面的研究.
通讯作者: 庄建良, 362000, 福建省泉州市东街256号, 福建医科大学附属泉州市第一医院肿瘤外科. zijiansue@gmail.com
电话: 0595-22277246
收稿日期: 2006-10-30 接受日期: 2006-11-11
Expression of CD24 and its relationship with angiogenesis and tumor cell proliferation in colorectal carcinoma
Jian-Liang Zhuang, Zi-Jian Su, Qun-Xiong Pan, Rong-Yu Xu, Ming-Zhu Li
Jian-Liang Zhuang, Qun-Xiong Pan, Rong-Yu Xu, Ming-Zhu Li,Department of Oncological Surgery, the First Hospital of Quanzhou City, Fujian Medical University, Quanzhou 362000, Fujian Province, China
Zi-Jian Su,Postgraduate of 2004 Class from Fujian Medical University, Fuzhou 350001, Fujian Province, China
Correspondence to:Jian-Liang Zhuang, Department of Oncological Surgery, the First Hospital of Quanzhou City, Fujian Medical University, 256 Dongjie Road, Quanzhou 362000, Fujian Province, China. zijiansue@gmail.com
Received:2006-10-30 Accepted:2006-11-11
Abstract
AIM: To investigate the expression of CD24 and its role in the angiogenesis and tumor cell proliferation in colorectal carcinoma.
METHODS: Direct immunofluorescence flow cytometry (FCM) was used to detect the expression of CD24 in 66 specimens of colorectal carcinoma and normal colorectal tissues. The expression of CD24 protein was shown by the percentage of positive cells (PPC) and mean fluorescence index (MFI). The expression of CD34 and proliferating cell nuclear antigen (PCNA) in colorectal carcinoma were detected by immunohistochemistry. Microvessel density (MVD) was figured out according to the positive staining for CD34. The proliferation index of carcinoma cells was figured out according to the expression of PCNA.
RESULTS: The values of PPC and MFI were significantly higher in colorectal carcinoma tissue than that in the normal colorectal tissue (PPC: 90 ......
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