缺血预处理对高原大鼠肝脏缺血/再灌注损伤早期的影响
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朱应乾, 覃 云, 王茂旭, 杜富波, 刘厚东, 李素芝
缺血预处理;缺血再灌注;肝脏损伤;大鼠;高原,朱应乾,王茂旭,杜富波,刘厚东,李素芝,覃云,通讯作者:,InfluenceofischemicpreconditioningonearlyhepaticI,Rinjuryinratsathig
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朱应乾, 王茂旭, 杜富波, 刘厚东, 李素芝, 西藏军区总医院普通外科 西藏自治区拉萨市 850003
覃云, 西双版纳州公安边防支队机动大队 云南省西双版纳州 666108
通讯作者: 朱应乾, 850003, 西藏自治区拉萨市娘热北路66号, 西藏军区总医院普通外科. zyqwxh@163.com
电话: 0891-6280143
收稿日期: 2006-09-11 接受日期: 2006-11-16
Influence of ischemic preconditioning on early hepatic I/R injury in rats at high altitude
Ying-Qian Zhu, Yun Qin, Mao-Xu Wang, Fu-Bo Du, Hou-Dong Liu, Su-Zhi Li
Ying-Qian Zhu, Mao-Xu Wang, Fu-Bo Du, Hou-Dong Liu, Su-Zhi Li,Department of General Surgery, General Hospital of Tibet Military Command, Lhasa 850003, Tibet Autonomous Region, China
Yun Qin,Mobile Military Unit of Xishuangbanna Public Security Frontier Defence Detachment, Xishuangbanna 666108, Yunnan Province, China
Correspondence to:Ying-Qian Zhu, Department of General Surgery, General Hospital of Tibet Military Command, 66 Niangre North Road, Lhasa 850003, Tibet Autonomous Region, China. zyqwxh@163.com
Received:2006-09-11 Accepted:2006-11-16
Abstract
AIM: To find out the protective effect and mechanism of ischemic preconditioning (IPC) on early hepatic ischemia-reperfusion (I/R) injury in rats at high altitude.
METHODS: A total of 45 Sprague Dawley rats were divided into the sham operation, I/R and IPC group. The rats were sacrificed 1, 3, and 6 hours after reperfusion. The level of serum alanine aminotransferase (ALT, nkat/L), malondialdehyde (MDA, mmol/L) and nitrix oxide (NO, μmol/L) were detected.
RESULTS: The level of serum NO in IPC group was significantly higher than that in I/R group (1 h: 95 ......
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