非酒精性脂肪性肝炎与细胞因子
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王 征, 刘东戈
非酒精性脂肪性肝炎;肿瘤坏死因子-α;趋化因子;白细胞介素-6;脂肪细胞因子,王征,刘东戈,通讯作者:,Relationshipbetweencytokinesandnon-alcoholicsteatohepatitis,ZhengWang,Dong-GeLi
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王征, 刘东戈, 卫生部北京医院病理科 北京市 100730
通讯作者: 王征, 100730, 北京市, 卫生部北京医院病理科. wangzheng813@hotmail.com
电话: 010-85133881
收稿日期: 2006-09-29 接受日期: 2006-10-16
Relationship between cytokines and non-alcoholic steatohepatitis
Zheng Wang, Dong-Ge Liu
Zheng Wang, Dong-Ge Liu,Department of Pathology, Beijing Hospital, Ministry of Health, Beijing 100730, China
Correspondence to:Zheng Wang, Department of Pathology, Beijing Hospital, Ministry of Health, Beijing 100730, China. wangzheng813@hotmail.com
Received:2006-09-29 Accepted:2006-10-16
Abstract
Non-alcoholic steatohepatitis (NASH) is a kind of hepatic lesion that related to metabolism and its development and progression are closely associated with cytokines. Three categories of cytokines, including Th1/Th2 cytokines, chemokines and adipocytokines, are involved in the physiopathological process of NASH. In order to elucidate the significances of cytokines in the pathogenesis, serological diagnosis, and treatment efficacy evaluation of HASH, we reviewed the documents on the relationship between cytokines and non-alcoholic steatohepatitis.
Key Words: Non-alcoholic steatohepatitis; Tumor necrosis factor-α; Interleukin-6; Adipocytokine; Chemokine
Wang Z, Liu DG. Relationship between cytokines and non-alcoholic steatohepatitis. Shijie Huaren Xiaohua Zazhi 2007;15(3):266-271
摘要
非酒精性脂肪性肝炎(non-alcoholic steatohepatitis, NASH)是一种与代谢相关的肝脏病变, 其发生、发展均与细胞因子有密切的关系. 参与NASH病理生理过程的细胞因子归纳起来有3类, 即Th1、Th2细胞因子和趋化因子及脂肪细胞因子, 本文了回顾3类细胞因子与NASH发生、发展关系的最新研究进展, 从而阐明细胞因子在NASH发病机制、血清学诊断和治疗效果评价等方面的意义.
关键词: 非酒精性脂肪性肝炎; 肿瘤坏死因子-α; 趋化因子; 白细胞介素-6; 脂肪细胞因子
王征, 刘东戈. 非酒精性脂肪性肝炎与细胞因子. 世界华人消化杂志 2007;15(3):266-271
0 引言
非酒精性脂肪性肝炎(non-alcoholic steato-hepatitis, NASH)是无过度饮酒史, 与脂质及糖代谢紊乱有关的肝脏疾病. 在病理组织学上表现为: 肝细胞脂肪变性; 肝实质炎症反应, 主要是肝腺泡三区和门管区混合性炎症细胞浸润、肝细胞气球样变性及Mallory小体形成; 各种形式的肝纤维化[1] ......
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