围手术期腹腔或盆腔热灌注化疗治疗结直肠癌的临床应用
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魏志刚, 李国新, 甄莉, 黄祥成, 卿三华, 巴明臣, 崔书钟
腹腔,盆腔热灌注化疗;结直肠癌;围手术期魏志刚,李国新,甄莉,黄祥成,卿三华,巴明臣,崔书钟.围手术期腹腔或盆腔热灌注化疗治疗结直肠癌的临床应用. 世界华人消化杂志2007;15(4)416-420 热化疗过程中患者主要临床指标变化2.2并发症及毒副作用热灌注化疗后,1例发热
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魏志刚, 李国新, 甄莉, 黄祥成, 卿三华, 南方医科大学南方医院普通外科 广东省广州市 510515
巴明臣, 崔书钟, 广州医学院广州市肿瘤医院腹外二科 广东省广州市 510095
通讯作者: 李国新, 510515, 广东省广州市, 南方医科大学南方医院普通外科. ligx1966@126.com
电话: 020-61641682
收稿日期: 2006-11-08 接受日期: 2006-11-28
Clinical application of perioperative continous hyperthermic peritoneal or pelvic perfusion chemotherapy for colorectal cancer
Zhi-Gang Wei, Guo-Xin Li, Li Zhen, Xiang-Cheng Huang, San-Hua Qing, Ming-Chen Ba, Shu-Zhong Cui
Zhi-Gang Wei, Guo-Xin Li, Li Zhen, Xiang-Cheng Huang, San-Hua Qing,Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Ming-Chen Ba, Shu-Zhong Cui,Department of Abdominal Surgery, Guangzhou Cancer Hospital, Guangzhou Medical College, Guangzhou 510095, Guangdong Province, China
Correspondence to:Guo-Xin Li, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province,China. ligx1966@126.com
Received:2006-11-08 Accepted:2006-11-28
AbstractAIM: To evaluate the feasibility, safety, side effect, complications and short-term efficacy of perioperative (intraoperative and early postoperative) continuous hyperthermic peritoneal or pelvic perfusion chemotherapy (CHPPC) for colorectal cancer.
METHODS: Radical or palliative resection was performed in 20 patients with advanced colorectal cancer. During the operation, macroscopic intraperitoneal metastases were demolished with electrosurgical unit (ESU). The patients with colon cancer underwent CHPPC once using 5-fluorouracil (5-FU) and mitomycin during the operation, and then received 5-FU CHPPC once per day from postoperative day 1 to 4. The hyperthermic perfusion lasted 60-90 minutes with a volume of 3000 mL at 43-44℃. The patients with rectal cancer were treated with intraoperative CHPPC (using 5-FU and mitomycin) once ......
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