海风藤酮对急性胰腺炎大鼠的治疗作用
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王成果, 马庆久, 鲁建国, 何显力, 王 青, 杜锡林, 褚延魁
急性胰腺炎;海风藤酮;丙二醛;超氧化物歧化酶王成果,马庆久,鲁建国,何显力,王青,杜锡林,褚延魁.海风藤酮对急性胰腺炎大鼠的治疗作用. 世界华人消化杂志2007;15(4)399-402,王成果,马庆久,鲁建国,何显力,王青,杜锡林,褚延魁,通讯作
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王成果, 马庆久, 鲁建国, 何显力, 王青, 杜锡林, 褚延魁, 第四军医大学唐都医院普外科 陕西省西安市 710038
通讯作者: 马庆久, 710038, 陕西省西安市新寺路, 第四军医大学唐都医院普外科. tdsurg@fmmu.edu.cn
电话: 029-84777732 传真: 029-87292087
收稿日期: 2006-11-01 接受日期: 2006-11-16
Therapeutic effect of kadsurenone on acute pancreatitis in rats
Cheng-Guo Wang, Qing-Jiu Ma, Jian-Guo Lu, Xian-Li He, Qing Wang, Xi-Lin Du, Yan-Kui Chu
Cheng-Guo Wang, Qing-Jiu Ma, Jian-Guo Lu, Xian-Li He, Qing Wang, Xi-Lin Du, Yan-Kui Chu,Department of General Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
Correspondence to:Qing-Jiu Ma, Department of General Surgery, Tangdu Hospital, the Fourth Military Medical University, Xinsi Road, Xi’an 710038, Shaanxi Province, China. tdsurg@fmmu.edu.cn
Received:2006-11-01 Accepted:2006-11-16
AbstractAIM: To observe the effect of kadsurenone in the treatment of acute pancreatitis (AP) in rats.
METHODS: A total of 120 male Sprague Dawley rats were randomized into 3 groups: control group (n = 40), AP model group (n = 40) and kadsurenone treatment group (n = 40). The indexes including the plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD), amylase (AMY), the volumes of ascites, and pancreatitic pathology were observed at the 3rd, 6th, 12th and 24th hour.
RESULTS: The plasma levels of AMY, MDA, and the volumes of ascites were remarkably elevated while the plasma level of SOD was lowered in AP rats. Kadsurenone significantly decreased the plasma levels of AMY (24 h: 69.6 ± 6.7 mkat/L vs 136.6 ± 13.4 mkat/L,P < 0.01), MDA (24 h: 1.45 ± 0.19 nmol/L vs 1.98 ± 0.27 nmol/L, P < 0.05), and the volumes of ascites (24 h: 4.03 ± 1.36 mL vs 5.15±1.69 mL, P < 0.05), while increased the plasma level of SOD (24 h: 35.27 ± 8.34 nmol/L vs 19.03 ± 8 ......
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