【摘要】 目的 观察前列腺素E1对先天性心脏病合并肺动脉高压的血流动力学的影响。方法 将60例先天性心脏病肺动脉高压患者随机分为治疗组与对照组，对照组30例常规治疗，治疗组30例常规治疗基础上加前列腺素E1治疗。结果 治疗组临床症状、平均肺动脉压mPAP、动脉氧分压、动脉血氧饱和度有显著改善。结论 PGE1能显著改善临床症状，显著降低mPAP，提高动脉氧分压和动脉血氧饱和度，对先天性心脏病肺动脉高压治疗效果较好。

    【关键词】 先天性心脏病；肺动脉高压；前列腺素E1

    A study of PGE1 in treatment of pulmonary hypertension associated with congenital heart defect

    GONG Bin,ZHANG Zhi-yong,SU Xue-jia,et al.Department of Cardiothoracic Surgery,88 Hospital of PLA,Shandong Taian,271000,China

    【Abstract】 Objective To evaluate the effect of prostaglandin E1 with congenital heart defects and pulmonary hypertension.Methods 60 patients with congenital heart disease and pulmonary hypertension were randomly divided into therapeutic group and control group(30 case)were traditionally treated and the therapeutic group(30 case)were treated with prostaglandin E1 based on the traditional therapy.Results after administration of PGE1,the mean pulmonary artery pressure(mPAP)was significantly reduced,the PaO2 and SaO2 were significantly increased.Conclusion Prostaglandin E1 therapy have effetive on pulmonary hypertension associated with congenital heart defect. ......