【摘要】 目的 观察脂肪酸合成酶抑制剂浅蓝菌素对wistar大鼠生长及代谢的影响，探讨浅蓝菌素控制饮食与体重的作用机制。 方法 腹腔注射浅蓝菌素，测定大鼠体重及摄食的变化，同时测定血清生化指标，在试验结束后分离腹脂，并作病理学检查。 结果 在给药后连续7d摄食减少40%左右，与对照组和控制摄食组比较，试验组体重显著降低(P<0.05)，腹脂明显降低(P<0.01);而组织无病理学改变。血清三酰甘油下降(P<0.05)，血清游离脂肪酸上升(P<0.05)，血糖、尿素氮、白蛋白、球蛋白无明显改变。 结论 浅蓝菌素可明显抑制摄食和控制体重，是一种比较安全和有效的潜在的减肥药物。

    【关键词】 脂肪酸合成酶复合物;大鼠;生长;代谢

    Effects of Fatty Acid Synthase Inhibitor on Growth and Metabolism of Wistar Rat/

    TANG Bao-ding，LI Zhong-wen，WUTao，et al.Department of Cytobiology，Bengbu Medical College，Bengbu(233030)，China

    【Abstract】 Objective To observe the effects fatty synthase(FAS)inhibitor on the growth and metabolism of wistar rat and to investigate the mecha-nism of cerulenin on diet and body weight control.Methods The wistar rats were interaperitoneal injected with cerulenin.The body weight change of diet and biochemical indices were assayed.The abdominal fat was separated and diagnosed by pathological examination.Results Food intake decreased by40%after the injection of cerulenin in the test group.Compared with the control group and restrictive diet group ......