Efficacy and safety of tinidazole adhesive tablet in the treatment of periodontitis

    WU Junª²Zhen1£¬WANG Qinª²Tao1£¬ZHOU Wei1£¬ WEN Deª²Sheng1£¬WANG Baoª²Yan2£¬CHANG Xiaoª²Feng2£¬ZHANG Jun3£¬DONG Jinª²Feng3, XIA Jieª²Lai4

    1National Research Center for Clinical Pharmacology, Dental Hospital, 4Department of Health Statistics, School of Military Preventive Medicine, Fourth Military Medical University, Xi¬ðan 710033, China£¬ 2Dental Hospital£¬Xi¬ðan Jiaotong University, Xi¬ðan 710004, China, 3Department of Dentistry, People¬ðs Hospital of Shaanxi Province, Xi¬ðan 710068, China

    ¡¾Abstract¡¿ AIM: To evaluate the efficacy and safety of tinidazole adhesive tablet in the treatment of periodontitis. METHODS: In the randomized, double blind, parallelª²group, controlled and multicenter study, 160 adult cases of periodontitis were divided evenly into experimental group and control group. The former was treated with tinidazole adhesive tablet (TAT, 5 mg/piece) and the latter with oral tinidazole tablet (OTT, 500 mg/piece). TAT was adhered onto the buccal gingival surface facing to the cheek between every 2 adjacent premolars and molars following mouth washing after breakfast and after dinner (1 piece per tooth, 2/d). OTT was given at 2 pieces per day respectively after breakfast and after dinner. TAT placebo was administered in control group and OTT placebo in experimental group in the same manner (2 pieces per day, respectively after breakfast and after dinner). The treatment was lasted for 5 d. Before and after treatment sulcus bleeding index (SBI), pocket depth (PD), tooth mobility (TM) and plaque index (PLI) were measured, subgigival bacteria flora (SBF) was examined, blood routine tests, liver function tests and renal function tests were conducted. RESULTS: Treatment was completed in 75 and 70 cases in the experimental and control groups respectively. The distribution of age, sex, nationality and occupation in the 2 groups were not significantly different (P>0.05). Before treatment, no statistic difference was found in SBI, PD, TM ......