结核；_肺；_护肝片；_药物毒性_____结核；

护肝片防治抗结核药物肝损害的临床观察

http://www.100md.com 《时珍国医国药》 2006年第11期

结核；,肺；,护肝片；,药物毒性,,结核；,肺；,护肝片；,药物毒性,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的观察护肝片对抗结核药物所致肝损害的防治效果。方法初治肺结核168例，应用“2HRZE(S)/4HR”方案抗结核治疗，治疗组88例，全程加服护肝片；对照组80例，全程加服葡醛内脂片。结果治疗组出现肝损害6例(6.82%)，其中 HBsAg阳性患者出现5例(5.68%)；对照组出现肝损害26例(32.50%)，其中 HBsAg阳性患者出现20例(25.00%)。两组比较有显著性差异(P<0.01)。HBsAg阳性患者在抗结核治疗中肝功能更容易受损害。结论护肝片在防治抗结核药物所致肝损害的发生是有效的，特别是对 HBsAg阳性的结核病患者。

    关键词：结核；肺；护肝片；药物毒性

    The Clinical Observation on the Preventive Effects of HuGan Tablets on Liver Damage Caused by Antituberculosis Drugs

    DING Weimin,ZHANG Lijuan,YANG Xiuyun

    (The First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China)

    Abstract:ObjectiveTo determine the preventive effect of HuGan Tablets on liver damage caused by anti-tuberculosis drugs.Methods168 initially-treated pulmonary tuberculoses patients who received the regimen of 2HRZE (S) /4HR were randomly separated into 2 groups:study group ,88 cases ,supplemented with Hu-Gan Tablets for 6 months and control group,80 cases,received glucurolactone.ResultsThere were 6 cases who had liver damage in observe group(6.82%) ,5 cases with HBsAg positive (5.68%) . There were 26 cases who had liver damage in control guoup (32.50%) ,20 cases with HBsAg positive (25.00%) .There were significant difference between the 2 groups (P<0.01) .HBsAg positive patients were more likely to have liver damage in antituberculosis treatment.ConclusionHuGan Tablets is effective in preventing and treating liver damage caused by anti-tuberculosis drugs,HBsAg positive patients' liver function should be monitored in the early period of anti-tuberculosis treatment. ......

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