急性冠状动脉综合征患者妊娠相关血浆蛋白A和白细胞介素6的变化
妊娠相关血浆蛋白A；白细胞介素6；急性冠状动脉综合征；,动脉粥样硬化,,妊娠相关血浆蛋白A；白细胞介素6；急性冠状动脉综合征；,动脉粥样硬化,1资料与方法,1.2方法,2结果,3讨论
【摘要】 目的 观察急性冠状动脉综合征( ACS)患者血清妊娠相关血浆蛋白A(PAPPA)和白细胞介素6(IL6)水平的变化及其之间的相关性，并探讨其临床意义。方法 选择46例ACS患者，其中急性心肌梗死(AMI组)20例、不稳定型心绞痛(UA组)26例，22例稳定型心绞痛(SA组)患者和20例正常对照者，采用ELISA 双抗体夹心法检测血清PAPPA和IL6水平。结果 ACS组PAPPA和IL6的浓度显著高于SA组和对照组(P<0.05或P<0.01), 后两者之间差异无显著性; ACS患者PAPPA和IL6之间存在直线正相关关系(r=0.62，P<0.01)。 结论 PAPPA和IL6是与ACS冠状动脉粥样斑块不稳定相关的血清学指标。【关键词】妊娠相关血浆蛋白A；白细胞介素6；急性冠状动脉综合征； 动脉粥样硬化
Relationship between serum pregnancy associated plasma proteinA and interleukin6 in patients with acute coronary syndrome BAI Xiaoyi, LIU Meixia,MI Jie.Department of Geriatrics, The People's Hospital of Hebei Province, Shijiazhuang 050051【Abstract】 Objective To investigate the changes of serum pregnancy associated plasma protein A (PAPP A),Interleukin6(IL6)concentrations in various types of coronary heart disease，and clarify their clinical significances.Methods Sixty eight patients with ischemic heart disease were included and allocated into 3 groups based on the findings of coronary angiography:stable angina pectoris group (SA,n=22), unstable angina pectoris group (UA,n=26),as well as acute myocardial infarction group (AMI,n=20). Twenty healthy subjects (according to the results of routine laboratory test,physical examination, and coronary angioplasty) were included in this study as control group.The levels of PAPP A and IL 6 were measured by using ELISA.Results The serum levels of PAPP A and IL6 in acute phase of UA and AMI increased statistically compared with those in control group and SA (P<0.05 and 0.01).There were no significant differences between control group and SA. The serum level of IL 6 was correlated with the serum level of PAPP A in patients with acute coronary syndrome (r=0.62,P<0.01).Conclusion It is suggested that the serum levels of PAPP A and IL6 in acute phase of the pathophysiological process increased,probable as a marker of unstable plaque in coronary heart disease. ......
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