Relationship of vascular endothelial growth factor and p33ING1 with biological behaviors of gastric carcinoma

    LIANG Qiª²Lian, CHEN Xiaoª²Dong, WANG Sanª²Ming, LI Jianª²Wen, ZHENG Zhaoª²Hui, HUANG Bing

    Oncology Center, Affiliated Hospital, Guangdong Medical College, Zhanjiang 524001, China

    ¡¾Abstract¡¿ AIM: To study the expressions of vascular endothelial growth factor(VEGF) and P33ING1 in gastric carcinoma, and their relations to the clinicopathological features. METHODS: VEGF protein and P33ING1 protein expressions in 102 cases of human gastric carcinoma tissues and normal tissues around the foci were examined by using immunohistochemistry. RESULTS: The expression of VEGF was high in carcinoma tissues while low in normal tissues(¦Ö2=68.0, P<0.01), as for P33ING1, the patter was contrary(¦Ö2=40.3, P<0.01). The expression of VEGF was related to serosa invasion, TNM stage, lymph node metastasis and 5ª²year survival rate (P<0.05). There was a close relation between the expression of P33ING1 and tumor location, serosa invasion, TNM stage, lymph node metastasis and 5ª²year survival rate (P<0.05). CONCLUSION: VEGF and P33ING are positively correlated with biological behaviors of gastric carcinoma, suggesting that examination by using immunohistochemistry for VEGF and P33ING1 may be of value in making diagnosis, evaluating evolution of disease in patients with gastric carcinoma at the same time. ......