Expression of Fascinª²1 in human colorectal cancer and its significance

    LIU Li, DING Yanª²Qing

    Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

    ¡¾Abstract¡¿ AIM: To investigate the correlation between Fascinª²1 expression and carcinogenesis and biological behavior of colorectal cancer (CRC). METHODS: The expression of Fascinª²1 was examined in 80 specimens of CRC, 40 of paired normal colorectal mucosae and 37 of regional lymphatic metastases by immunohistochemical method. RESULTS: Fascinª²1 was expressed heterogeneously among the normal colorectal mucosae, CRC and lymphatic metastases (¦Ö2£½30.917, P=0.000). Fascinª²1 was higher expressed in CRC compared with normal colorectal mucosae (Z=-3.912, P=0.000), and Fascinª²1 expression was significantly stronger in lymphatic metastases than that in primary CRC (Z£½-2.419, P=0.016). Furthermore, Fascinª²1 expression in CRC with lymph node metastasis was higher than that in CRC without lymph node metastasis (Z=-2.432, P£½0.015). Expression levels of Fascinª²1 protein, showing no correlation with the differentiation of CRC (¦Ö2£½0.333, P=0.847), was positively correlated with the invasive depth of CRC (Z=-2.074, P=0.038). CONCLUSION: Fascinª²1 expression plays an important role in invasion and metastasis of CRC. Clinically it may be a useful indicator of the tumor invasion and metastasis in CRC. ......