胃黏膜损伤；_虎杖苷；_无水乙醇；

虎杖苷对实验性急性胃黏膜损伤的保护作用

http://www.100md.com 《时珍国医国药》 2006年第11期

胃黏膜损伤；,虎杖苷；,无水乙醇；,吲哚美辛；,束缚-冷冻应激,,胃黏膜损伤；,虎杖苷；,无水乙醇；,吲哚美辛；,束缚-冷冻应激,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的研究虎杖苷(polydatin,PD)对实验性急性胃黏膜损伤的保护作用及其与抗氧化的关系。方法制备小鼠无水乙醇型、吲哚美辛(消炎痛)型、大鼠束缚-冷冻(restraint-cold stress,RCS)应激型胃黏膜损伤模型，测定胃黏膜损伤指数；测定大鼠血清 SOD活性和 MDA含量。结果PD可剂量依赖性地抑制实验性急性胃黏膜损伤。PD可使大鼠束缚冷冻应激型胃黏膜损伤过程中血清中升高的 MDA含量降低，可使降低的 SOD水平回升。结论PD对实验性急性胃黏膜损伤具有保护作用，其作用机制与 PD抗氧化有关。

    关键词：胃黏膜损伤；虎杖苷；无水乙醇；吲哚美辛；束缚-冷冻应激

    Protective Effect of Polydatin on Experimental Acute Gastric Mucosal Lession in Rats

    GUO Jieyun, ZHU Wenqing,ZHAO Weizhong,WANG Lin

    (Department of Pharmacology,Anhui Medical University,Hefei 230032, China; Dept of Cardiac Surgery, Anhui Provincial Children's Hospital, Hefei 230051, China)

    Abstract：ObjectiveTo study the protective effect of polydatin(PD) on experimental gastric mucosal lesion in rats and relationship of antioxidative effect.MethodsMake the model of gastric mucosal lesion in rats induced by ethanol absoute ,RCS and indomethacin;the index of gastric mucosal lesion in rats was determined;the contents of MDA and SOD of serum were measured.ResultsThe index of experimental gastric mucosal lesion in rats was inhibited after administration of PD,the decrease of SOD of serum was elevated to normal level .ConclusionPD can possess protective effect on experimental gastric mucosal lesion in rats .Its mechanism may be related to antioxidative effect . ......

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