党参；_天麻；_抗氧化酶；_超氧化物歧化酶；

党参与天麻对氟哌啶醇致老化大鼠抗氧化酶表达作用的比较研究

http://www.100md.com 《时珍国医国药》 2006年第9期

党参；,天麻；,抗氧化酶；,超氧化物歧化酶；,谷胱甘肽过氧化物酶,,党参；,天麻；,抗氧化酶；,超氧化物歧化酶；,谷胱甘肽过氧化物酶,1材料与方法,2结果与分析,3讨论,参考文献：

     摘要：目的观察和探讨党参、天麻对氟哌啶醇诱导老化大鼠抗氧化酶表达作用的影响。方法雄性Wister大鼠40只，随机分为对照组、模型组、实验1组、实验2组。除对照组外，模型组、实验组均用氟哌啶醇建立痴呆症(Alzheimer Disease,AD)动物模型，实验组还分别腹腔注射党参注射液、天麻注射液。测定各组大鼠血、肝、肾、海马、脑皮质中超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSHPX)含量。结果与对照组、模型组比较，党参注射液和天麻注射液均能使实验大鼠多种组织SOD、GSHPX显著升高，差异有非常显著性意义(P<0.001)。结论党参和天麻都能增强抗氧化酶表达作用，但在升高SOD和GSHPX的表达值上，二者则无明显差别。

    关键词：党参；天麻；抗氧化酶；超氧化物歧化酶；谷胱甘肽过氧化物酶

    The Comparison Between Radix Codonopsis Pilosulae and Gastrodia elata Blume on the Expression of Antioxidase of Aging Rat Induced by Haloperidol

    HUANG Liya, YE Siying, LIU Jieshu

    (Medical School, Hubei College of Nationality, Enshi, Hubei 445000,China; Medical College of Jinan University, Guangzhou, Guangdong 510632, China)

    Abstract:ObjectiveTo study the effect of Radix codonopsis pilosulae and Gastrodia elata Blume on the expression of antioxidase of aging rat induced by haloperidol.Methods40 male Wistar rats were randomly divided into control,model,test group 1 and 2.Rat model of Alzheimer Disease induced by haloperidol were employed. Except control group,the rats of test group 1 and 2 were injected with Radix codonopsis pilosulae injection and Gastrodia elata Blume injection respectively and meanwhile concentrations of SOD and GSHPX in serum,liver,kidney,hipocampus and cortex of the animal were detected.ResultsIn contrast with control and groups,concentrations of SOD and GSHPX obviously increased,the differences were statistically significant(P<0.001).ConclusionRadix codonopsis pilosulae and Gastrodia elata Blume can be in upregulating expression of antioxidase.But the two herbs have similar activities of antioxidation. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/02/17/37/50/87.htm

您现在查看是摘要页，全文长 8060 字符。