复方大果木姜子软胶囊；_FM1；

复方大果木姜子软胶囊抗流感病毒作用的体外实验研究

http://www.100md.com 《时珍国医国药》 2006年第10期

复方大果木姜子软胶囊；,FM1；,MDCK；,抑制病毒增殖；,抗病毒活性,,复方大果木姜子软胶囊；,FM1；,MDCK；,抑制病毒增殖；,抗病毒活性,1材料及方法,2结果,3讨论,参考文献：

     摘要：目的对复方大果木姜子软胶囊进行体外抗流感病毒实验研究，开发安全有效的抗流感病毒的中药新药。方法细胞培养实验方法。结果复方大果木姜子软胶囊在MDCK细胞中的半数中毒浓度(TC50)为1.248 mg·ml-1；预防组抗流感病毒的半数有效浓度(EC50)为0.117 mg·ml-1；治疗指数(TI)为10.67；感染病毒0~7 h后均有明显的抑制FM1在MDCK细胞中增殖的作用。结论复方大果木姜子软胶囊对流感病毒FM1在MDCK细胞中的增殖具有明显的抑制作用。

    关键词：复方大果木姜子软胶囊； FM1； MDCK；抑制病毒增殖；抗病毒活性

    Anti-influenza Effect of Fufang Daguomujizngzi Ruanjiaonang in vitro

    HU Wanfu,ZHANG Yongping, QIU Dewen

    (Guiyang College of TCM, GuiYang, GuiZhou 550002,China)

    Abstract：ObjectiveTo observe the effect of anti-virus by compound-herbs china momum migao H.W.Li soft capsule,to develop an effective new drug of anti-virus.MethodsThe cell culture experiment.ResultsIt was found to be a potential inhibitor of influenza FM1 virus in a concentration-dependent manner with a TC50of 1.248 mg·ml-1 in MDCK culture. The EC50 was 0.117 mg·ml-1(TI=10.67) when drug was added for 0~7 hours after virus infection. ConclusionThere might be a quantity-effect relationship and it has notable restrain effect. ......

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