复方苦豆子颗粒；_高脂血症；_血脂；_丙二醛_

复方苦豆子颗粒对高脂血症大鼠血脂及脂质过氧气化物的影响

http://www.100md.com 《时珍国医国药》 2006年第10期

复方苦豆子颗粒；,高脂血症；,血脂；,丙二醛,,复方苦豆子颗粒；,高脂血症；,血脂；,丙二醛,1仪器与材料,2方法,3结果,4讨论,参考文献：

     摘要：目的观察复方苦豆子颗粒对高脂血症大鼠血脂水平的影响和抗脂质过氧化作用。方法采用喂养高脂饲料的方法复制高脂血症大鼠模型，随机分组，实验10周后测定血脂水平、动脉粥样硬化脂数(AI)、血清 MDA及肝组织中 TC、MDA的含量。结果与高脂模型相比，复方苦豆子颗粒组大鼠血清 TC、TG、LDLC水平和动脉粥样硬化指数(AI)明显降低(P<0.05~0.01)，血清 MDA含量显著降低(P<0.01)，且呈剂量依赖性；大剂量组可明显升高 HDLC含量(P<0.05)；复方苦豆子颗粒各剂量组肝组织 TC无显著性差异(P<0.05)，中剂量可明显降低肝组织 MDA水平(P<0.05)，小剂量组和大剂量组无显著性差异(P>0.05)。结论复方苦豆子颗粒具有明显的调血脂、抑制脂质过氧化物MDA形成的作用。

    关键词：复方苦豆子颗粒；高脂血症；血脂；丙二醛

    Effect of Complex Prescription Kudouzi Granule on Blood Lipid and LPO of Hyperlipidemia Rats

    CAO Yajun, MA Jianhui, CHEN Hong*, LI Liyan

    (Key Laboratory of Phytomedicine Resources ＆ Modernization of TCM, Xinjiang Building Army, Shi hezi, Xinjinag 832002,China)

    Abstract:ObjectiveTo observe the influence on the serum lipid level and antilipid perxidation effect of compound prescription Kudouzi granule on blood lipid metabolic disorder in hyperlipidemia rats.MethodsAdopting the hyperlipidemia rats fed with the high lipid diet and dividing randomly into guoups .After 10 weeks, the serum lipid, atherosclerosis index(AI), serum MDA, hepatic TC,and hepatic MDA were tested.ResultsCompared with the high lipid model group,Kudouzi granule compound prescription could obviously decrease the serum level of TC,TG,LDLC,MDA and atheroslerosis index (AI)(P<0.05~0.01)and elevate the HDLC level obviously(P<0.05)in high dose group ,also indicated the dosage dependence .Hepatic TC of different dose groups did not have the significance difference(P>0.05).Hepatic MDA level was obviously reduced(P<0.05)in middle dose group,but did not have the significance difference(P>0.05)in low and high dose groups.ConclusionThe compound prescription Kudouzi granule has prominent effect on regulating the serum lipid level and decreasing the MDA level. ......

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