甘草酸；_支气管哮喘；_免疫调节____

甘草酸防治小鼠哮喘的作用及其免疫学机理探讨

http://www.100md.com 《时珍国医国药》 2006年第8期

甘草酸；,支气管哮喘；,免疫调节,,甘草酸；,支气管哮喘；,免疫调节,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的观察甘草酸对小鼠哮喘的防治作用及对哮喘小鼠的血清IgE和IL4的影响。方法建立小鼠哮喘模型, 观察甘草酸对小鼠哮喘模型及哮喘小鼠血清IgE和IL4影响。结果甘草酸治疗后与哮喘组小鼠相比较小鼠肺组织的炎症病理变化明显减轻, 血清IgE和IL4的水平均降低。结论甘草酸具有免疫抑制作用, 可能通过调节机体的免疫功能，而发挥其抗支气管哮喘免疫炎症反应。

    关键词：甘草酸；支气管哮喘；免疫调节

    Effect of Glycyrrhizin on Mice Model of Bronchial Asthma and Immunology Mechanism

    L Xiaohua， WU Tie， QIN Dongyun

    (Department of Pharmacology ,Guangdong Medical College, Zhanjiang 524023，China)

    Abstract：ObjectiveTo explore the effect of glycyrrhizin on mice model of bronchial asthma and serum IgE and IL4 . MethodsThe mice model of bronchial asthma was built up. The effect of glycyrrhizin on mice model of bronchial asthma were observed, and the level of serum IgE and IL4 were tested. ResultsCompared with the model group, decreased in the group of glycyrrhizln inflammatary cells infiltration in pulmonary tissue slices of tiny bronchial wall and serum IgE and IL4 level.ConclusionGlycyrrhizin have immunosuppressive action, and can inhibit bronchial asthma immuno-inflammation by regulating organism immune function. ......

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