膀胱移行细胞癌；信号转导；DNA芯片_

DNA芯片技术筛选膀胱移行细胞癌信号转导相关基因

http://www.100md.com 《现代泌尿外科杂志》 2000年第1期

膀胱移行细胞癌；信号转导；DNA芯片,,膀胱移行细胞癌；信号转导；DNA芯片,关键词：膀胱移行细胞癌；信号转导；DNA芯片,1材料与方法,2结果,3讨论,参考文献：

     DNA chip analysis of signal transduction genes in human urinary bladder transitional cell carcinoma

    Zhang Keqin, Jin Fengshuo, Ye Jin, Sun Zhongyi, Zhang Yong, Wu Gang, Gao Lin

    (Department of Urology, Insititute of Surgery, Third Affiliated Hospital of Third Military Medical University, Chongqing 400042, China)

    ABSTRACT: Objective To investigate the change of signal transduction genes in human transitional cell carcinoma (TCC). Methods DNA chip was used to detect the mRNA from 11 human transitional cell carcinoma tissues and to investigate the genes related to signal transduction. Results Contrast to normal bladder mucous membrane tissues, there were 189 differentially expressed genes, in which 102 genes were obviously upregulated and 87 genes were obviously downregulated in human TCC tissues. There were 35 differentially expressed genes related to signal transduction, in which 13 genes were obviously upregulated and 22 genes were obviously downregulated. Conclusion Many differentially expressed genes related to signal transduction play a role in the development of bladder transitional cell carcinoma. ......

百拇医药网 http://www.100md.com/html/DirDu/2007/02/17/37/60/88.htm

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