脑梗死患者Hcy及MTHFR基因多态性与颈动脉IMT的关系
脑梗死；同型半胱氨酸；5,10-亚甲基四氢叶酸还原酶；颈动脉IMT,,脑梗死；同型半胱氨酸；5，10-亚甲基四氢叶酸还原酶；颈动脉IMT,1资料与方法,2结果,3讨论,【参考文献】
脑梗死患者Hcy及MTHFR基因多态性与颈动脉IMT的关系 (pdf)【摘要】 目的 探讨Hcy、MTHFR C677T基因多态性与颈动脉IMT及脑梗死之间的关系。方法 观察42例脑梗死患者和40例对照者，用循环酶法测定Hcy水平，采用聚合酶链反应-限制片长多态性方法检测MTHFR基因多态性，用彩色多普勒检查颈动脉IMT。结果 病例组血清Hcy 浓度显著高于对照组；Hcy是颈动脉IMT增厚及脑梗死的促进因素；MTHFR基因多态性非颈动脉IMT增厚及脑梗死的危险因素。结论 血清Hcy升高是动脉粥样硬化及脑梗死的独立危险因素，单纯的MTHFR尚不能认为是动脉粥样硬化及脑梗死的独立危险因素。
【关键词】 脑梗死；同型半胱氨酸；5，10-亚甲基四氢叶酸还原酶；颈动脉IMT
The relationship between homocysteine，MTHFR gene polymorphism and carotid intima-media thickness in cerebral infarction patients
SHEN Yuan,YU Hua-feng,LU Bo-hua,et al.Department of Neurology,Tongren Hospital,Beijing 100076,China
【Abstract】 Objective To investigate the relationship of homocysteine(Hcy) level and genetic polymorphisms of methylenetetrahydrofolate reductase(MTHFR) related to homocysteine metabolism with carotid intima-media thickness(IMT)in cerebral infarction patientsMethods In 42 cerebral infarction patients and 40 healthy people，serum Hcy level was measured by cyclophorase assay；MTHFR genetic C677T polymorphism was determined by polymerase chain reaction；carotid intimal-medial wall thickness was determined by the use of the duplex ultrasonographyResults The Hcy level in the patient group was significantly higher than that in the control group (P<0001) Hcy is related to the thickness of carotid intimal-medial thikness and cerebral infarction even after controlling for other traditional risk factors ......
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