溶血性、非溶血性肠球菌的毒力差异
肠球菌属;,溶血素类;,毒力;,药物耐受性,,肠球菌属;,溶血素类;,毒力;,药物耐受性,1材料与方法,2结果,3讨论,参考文献：
摘要:目的 探讨肠球菌溶血素与毒力的关系。方法 比较溶血性肠球菌在临床标本及健康人群粪便标本的检出率;比较溶血性、非溶血性肠球菌对小鼠的LD50及其对9种抗生素的敏感性。结果 临床标本肠球菌的溶血素检出率61.5%,高于健康人群粪便标本(18.4%,P<0.05);溶血性肠球菌的LD50\[(3.9~11)×108cfu/mL\]比非溶血性肠球菌小\[(2.5~8.9)×1010cfu/mL,P<0.01\]。除丁胺卡那、万古霉素外，溶血性肠球菌对抗生素的耐药性明显高于非溶血株。结论 肠球菌的溶血素可能与其毒力有关。关键词:肠球菌属; 溶血素类; 毒力; 药物耐受性
Difference of Enterococci Virulence between Hemolytic and Non Hemolytic Strains
Qiang Hua, Xie Manling
Division of Etiology, Fujian Medical University, Fuzhou 350004, China
ABSTRACT: Objective To investigate the relation between enterococcus hemolysin and its virulence. Methods Incidence of hemolysin of enterococci derived from clinical isolates and healthy people fecal specimens were examined respectively; LD50 and antibiotic susceptibilities were compared between hemolytic strains and non hemolytic strains. Results Strains derived from clinical isolates exhibited higher(61.5%) incidence of hemolysin than that from healthy people fecal speciments(18.4%, P<0.05). The LD50 of hemolytic strains \[(3.9~11) 108cfu/mL\] were at least 10fold higher than those of nonhemolytic strains\[(2.5~8.9) 1010cfu/mL\], P<0.01. Hemolytic strains were found to be more resistant to all the 9 antibiotics tested, except amikacin and vancomycin. Conclusion These results implied that hemolysin may contribute to the virulence of enterococci. ......
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