谷胱甘肽转硫酶T1基因型与溃疡性结肠炎易感性的关系
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王文星, 夏宣平, 蒋 益, 林李淼, 张定亮, 曹曙光
谷胱甘肽转硫酶;基因型;溃疡性结肠炎;易感性,王文星,夏宣平,蒋益,林李淼,张定亮,曹曙光,通讯作者:,AssociationbetweengeneticpolymorphismofglutathioneS-TransferaseT1andth
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王文星, 夏宣平, 蒋益, 林李淼, 张定亮, 曹曙光, 温州医学院附属第二医院消化科 浙江省温州市 325027
温州市科技局资助项目, No. W2004A065
通讯作者: 王文星, 325027, 浙江省温州市, 温州医学院附属第二医院消化科. jaccostar@163.com
电话: 0577-88816311 传真: 0577-88816411
收稿日期: 2006-11-09 接受日期: 2006-12-18
Association between genetic polymorphism of glutathione S-Transferase T1 and the susceptibility to ulcerative colitis
Wen-Xing Wang, Xuan-Ping Xia, Yi Jiang, Li-Miao Lin, Ding-Liang Zhang, Shu-Guang Cao
Wen-Xing Wang, Xuan-Ping Xia, Yi Jiang, Li-Miao Lin, Ding-Liang Zhang, Shu-Guang Cao,Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Supported bythe Fund from Science and Technology Bureau of Wenzhou City, No. W2004A065
Correspondence to:Wen-Xing Wang, Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, Zhejiang Province, China. jaccostar@163.com
Received:2006-11-09 Accepted:2006-12-18
Abstract
AIM: To investigate the association between the genetic polymorphism of glutathione S-Transferase T1 and the susceptibility to ulcerative colitis.
METHODS: Polymerase chain reaction (PCR) was used to study the genetic polymorphisms of GSTT1 gene, then the discrepancies of GSTT1 gene polymorphism between the patients with ulcerative colitis and the healthy controls were analyzed using chi-square test.
RESULTS: The frequency of null genotype for GSTT1 was significantly higher in the patients with ulcerative colitis than that in the controls (64.7% vs 47.1%, P = 0.007, OR = 2.050, 95%CI: 1.208-3.480). Further analysis showed that the frequency of GSTT1 null genotype was also higher in the patients with distal colitis than that in the cases with total colitis (71.8% vs 31.3%, P = 0.002, OR = 5.408, 95%CI: 1.698-17.231). There was no correlation between the frequency of GSTT1 null genotype and the severity degree of ulcerative colitis (P > 0 ......
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