乙肝III号内外合用治疗慢性乙型肝炎后肝纤维化63例
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邢宇锋, 张 希, 邵 丽, 王丽娜, 童光东
慢性乙型肝炎;肝纤维化;中药;内外合用,邢宇锋,张希,邵丽,王丽娜,童光东,通讯作者:,Long-termefficacyofcombinedinternalandexternalapplicationofGanyanSanhaointrea
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邢宇锋, 张希, 邵丽, 王丽娜, 童光东, 广州中医药大学附属深圳医院肝病科 广东省深圳市 518033
深圳市科技资助项目, NO. 200204239
通讯作者: 童光东, 518033, 广东省深圳市福华路1号, 广州中医药大学附属深圳医院肝病科. tgd755@163.com
电话: 0755-88359666-1005
收稿日期: 2006-11-20 接受日期: 2006-12-18
Long-term efficacy of combined internal and external application of Ganyan Sanhao in treatment of liver fibrosis resulted from chronic hepatitis B
Yu-Feng Xing, Xi Zhang, Li Shao, Li-Na Wang, Guang-Dong Tong
Yu-Feng Xing, Xi Zhang, Li Shao, Li-Na Wang, Guang-Dong Tong,Department of Hepatology, Shenzhen Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen 518033, Guangdong Province, China
Correspondence to:Guang-Dong Tong, Department of Hepatology, Shenzhen Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen 518033, Guangdong Province, China. tgd755@163.com
Received: 2006-11-20 Accepted:2006-12-18
Abstract
AIM: To observe the prospective efficacy of integrated internal and external application of Yigan Sanhao (YGSH) in the treatment of liver fibrosis resulted from chronic hepatitis B (CHB).
METHODS: A total of 240 inpatients with CHB-induced liver fibrosis were randomly divided into group A (n = 58), B (n = 62), C (n = 63) and D (n = 57). External, internal and integrated external and internal treatments of YGSH were performed on the patients of group A, B, and C, respectively. The patients of group D served as controls. The clinical symptoms, liver function, fibrosis and PGA parameters, and hemodynamic changes were observed 3 months after treatment.
RESULTS: The clinical symptoms were improved, especially in group C. The liver function, fibrosis and PGA parameters were also ameliorated 3 months after treatment in all the groups, especially in group C (t = 6.1201, P = 0.000; t = 20.8201, P = 0.000; t = 20.5154, P = 0.000). Hemodynamic examination showed that the diameters of splenic and portal vein as well as the blood flow were decreased in all the groups (t = 3 ......
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