肠内生态营养对创伤后大鼠肠屏障功能的影响
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余利坚, 徐 亮, 姚 晖, 魏仁志, 綦晓龙
肠内营养;生态营养;肠黏膜屏障;Wistar大鼠,余利坚,徐亮,姚晖,魏仁志,綦晓龙,通讯作者:,Effectsofenteraleconutritiononintestinalmucosalbarrierfunctioninwoundedrats
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余利坚, 泸州市人民医院普外科 四川省泸州市 646000
徐亮, 姚晖, 魏仁志, 綦晓龙, 泸州医学院附属医院胃肠外科 四川省泸州市 646000
通讯作者: 徐亮, 646000, 四川省泸州市, 泸州医学院附属医院胃肠外科. yulijianyouxiang@sina.com
电话: 0830-2392712-5448 传真: 0830-2392718
收稿日期: 2006-11-28 接受日期: 2006-12-18
Effects of enteral econutrition on intestinal mucosal barrier function in wounded rats
Li-Jian Yu, Liang Xu, Hui Yao, Ren-Zhi Wei, Xiao-Long Qi
Li-Jian Yu,Department of General Surgery, Luzhou People’s Hospital, Luzhou 646000, Sichuan Province, China
Liang Xu, Hui Yao, Ren-Zhi Wei, Xiao-Long Qi, Department of Gastrointestinal Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
Correspondence to: Liang Xu,Department of Gastrointestinal Surgery, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China. yulijianyouxiang@sina.com
Received: 2006-11-28 Accepted:2006-12-18
Abstract
AIM: To study effects of enteral econutrition on the function of intestinal mucosal barrier in wounded rats.
METHODS: A total of 30 Wistar rats were randomly and averagely divided into 3 groups, which received common forage (CF), enteral nutrition (EN) and enteral econutrition (EEN), respectively, for 7 days. The ileal membrane morphology and the numbers of IgA+, CD3+, CD4+ and CD8+ cells were examined.
RESULTS: The villus height (205.4 μm vs 177.7 μm, P < 0.05), crypt depth (99.4 μm vs 77.7 μm, P < 0.05), mucosal thickness (299.9 μm vs 267.0 μm, P < 0.05) and villus surface area (10 321.5 μm2 vs 8927.6 μm2,P < 0.05) of ileum were increased in EEN group as compared with those in control group, but there was no significance between EN and EEN group (P > 0.05). The quantities of IgA+ (21.2 vs 17.5, 19.4, P < 0.05), CD3+ (24.2 vs 20.2, 22.1, P < 0.05), CD4+ (13 ......
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