荆花胃康胶丸对大鼠胃黏膜的保护机制
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朱国琴, 施瑞华, 沈 健, 周清清, 郝 波
荆花胃康胶丸;胃黏膜损伤;前列腺素E2;表皮生长因子,朱国琴,施瑞华,沈健,周清清,郝波,通讯作者:,ProtectiveeffectofJinghuaWeikangJiaowanongastricmucosaofratsanditsmechanism,G
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朱国琴, 施瑞华, 沈健, 周清清, 郝波, 南京医科大学第一附属医院消化科 江苏省南京市 210029
通讯作者: 施瑞华, 210029, 江苏省南京市广州路300号, 南京医科大学第一附属医院消化科. ruihuashi@126.com
电话: 025-83718836-6032
收稿日期: 2006-11-06 接受日期: 2006-12-08
Protective effect of Jinghua Weikang Jiaowan on gastric mucosa of rats and its mechanism
Guo-Qin Zhu, Rui-Hua Shi, Jian Shen, Qing-Qing Zhou, Bo Hao
Guo-Qin Zhu, Rui-Hua Shi, Jian Shen, Qing-Qing Zhou, Bo Hao,Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondening to:Rui-Hua Shi, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. ruihuashi@126.com
Received:2006-11-06 Accepted:2006-12-08
Abstract
AIM: To explore the preventive and therapeutic effects of Jinghua Weikang Jiaowan (JWJ) on ethanol-induced acute gastric mucosal injury and the related mechanisms.
METHODS: Eighty-four rats were averagely randomized into 7 groups: null control group (I), prevention group (Ⅱ), treatment control group (Ⅲa), talcid treatment group (Ⅲb group), JWJ treatment groups (treated with 10, 20, and 30 mg/kg; named as Ⅲc, Ⅲd, Ⅲe, respectively). After 1, 3 and 7 days, the rats were killed to measure the injury index and the tissue contents of prostaglandin E2 (PGE2) and epidermal growth factor (EGF). Histological changes were observed at the same time.
RESULTS: JWJ resisted gastric mucosal injury and increased the tissue contents of PGE2 and EGF in dose- and time-dependent manners (P < 0.01 or P < 0.05). The inflammatory degree was obviously alleviated in group Ⅲb, Ⅲc, Ⅲd, and Ⅲe than that in group Ⅲa. Besides, the swelling and degeneration of mucosal cells were relieved and the number of inflammatory cells was decreased. The contents of mucosal PGE2 (3 d: 190 ......
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