糖尿病慢传输运动结肠Cajal间质细胞和干细胞因子的变化
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罗 云, 林 琳, 张红杰, 李学良, 吴高珏, 王美峰
干细胞因子;糖尿病;结肠慢传输运动;Cajal间质细胞,罗云,林琳,张红杰,李学良,吴高珏,王美峰,罗云,通讯作者:,AlterationofCajalinterstitialcellsandstemcellfactorsincolo
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罗云, 林琳, 张红杰, 李学良, 吴高珏, 王美峰, 南京医科大学第一附属医院消化内科 江苏省南京市 210029
罗云, 南京医科大学硕士研究生, 主要研究方向为胃肠动力性疾病.
江苏省“135工程”重点人才基金项目, No. RC2003087
江苏省自然科学基金项目, No. BK2004158
通讯作者: 林琳, 210029, 江苏省南京市, 南京医科大学第一附属医院消化内科. lin9100@yahoo.com.cn
电话: 025-83781836-6920
收稿日期: 2006-11-29 接受日期: 2006-12-18
Alteration of Cajal interstitial cells and stem cell factors in colon with slow transit motility of diabetes mellitus
Yun Luo, Lin Lin, Hong-Jie Zhang, Xue-Liang Li, Gao-Jue Wu, Mei-Feng Wang
Yun Luo, Lin Lin, Hong-Jie Zhang, Xue-Liang Li, Gao-Jue Wu, Mei-Feng Wang,Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Supported bythe Natural Science Foundation of Jiangsu Province, No. BK2004158, and the Fund from “135 Project” for the Key Talents of Health and Science Education Department of Jiangsu Province, No. RC2003087
Correspondence to:Lin Lin, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. lin9100@yahoo.com.cn
Received:2006-11-29 Accepted:2006-12-18
Abstract
AIM: To observe the alterations of interstitial cells of Cajal (ICC) and stem cell factors (SCF) in colon tissues with slow transit motility of diabetes mellitus, and study their roles and possible regulatory mechanism.
METHODS: A total of 54 male Sprague-Dawley rats were randomly and averagely divided into diabetes group and control group. Diabetes model was induced by intraperitoneal injection of streptozotocin. Nine rats of the above two groups were killed respectively 6, 8 and 10 weeks after injection. The alterations of ICC and membrane-bound SCF (M-SCF) in the proximal colon tissues were analyzed by immunohistochemistry, transmission electron microscopy and Western blot, and the serum concentration of soluble SCF (S-SCF) were examined by enzyme-linked immunosorbent assay (ELISA) ......
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