急性胰腺炎大鼠肺组织中水通道蛋白-1的表达及功能
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高振明, 陈海龙, 刘小东
急性重症胰腺炎;肺损伤;水通道蛋白-1;大鼠,高振明,陈海龙,高振明,通讯作者:,Expressionandfunctionofaquaporin-1inacutelunginjuryinducedbysevereacutepancrea
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高振明, 大连医科大学附属第二临床学院普外科 辽宁省大连市 116023
陈海龙, 刘晓东, 大连医科大学附属第一临床学院普外科 辽宁省大连市 116011
高振明, 医学硕士, 在读博士, 从事普通外科和中西医结合外科临床研究.
国家自然科学基金资助项目, No. 30271667
通讯作者: 陈海龙, 116011, 辽宁省大连市西岗区中山路222号, 大连医科大学附属第一临床学院普外科.
hailongchen2006@163.com
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收稿日期: 2006-12-01 接受日期: 2006-12-18
Expression and function of aquaporin-1 in acute lung injury induced by severe acute pancreatitis in rats
Zhen-Ming Gao, Hai-Long Chen, Xiao-dong Liu
Zhen-Ming Gao,Department of General Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Hai-Long Chen, Xiao-Dong Liu,Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Supported byNational Science Foundation of China, No. 30271667
Correspondence to:Hai-Long Chen, Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China. hailongchen20062163.com
Received:2006-12-01 Accepted:2006-12-18
Abstract
AIM: To investigate the expression of aquaporin-1 (AQP-1) in acute lung injury induced by severe acute pancreatitis (SAP) in rats, and to explore the relationship between AQP-1 expression and acute lung injury (ALI).
METHODS: Adult Wistar rats were randomly divided into 3 groups: sham operation (SO) group, ALI group and dexamethasone (DEX, 2 mg/kg via caudal vein) group. Sodium deoxycholate was (15 g/L) injected inversely into the biliopancreatic duct of rats to make the model of SAP-induced ALI. Eight rats of each group (n = 8) were killed 4, 8, 12 h respectively after SAP model was established, and blood samples and lung tissues were collected. Serum amylase, partial pressure of oxygen, lung wet-to-dry weight ratio (W/D) and pulmonary homogenate were measured to evaluate the degrees of pancreatic inflammation and ALI ......
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