一氧化氮、白介素、肿瘤坏死因子与肝硬化患者预后的关系
http://www.100md.com
孙 群, 张 强, 朱金水, 陈 玮, 陈尼维
肝硬化;一氧化氮;白细胞介素;肿瘤坏死因子;预后,孙群,张强,朱金水,陈玮,陈尼维,通讯作者:,电话:, 传真:,收稿日期:,接受日期:,Correlationsofserumnitricoxide,interleukin-
参见附件(1kb)。
孙群, 张强, 朱金水, 陈玮, 陈尼维, 上海交通大学附属第六人民医院消化科 上海市 200233
通讯作者: 朱金水, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化科. zhujs1803@hotmail.com
电话: 021-64369181-8969 传真: 0021-64837019
收稿日期: 2006-11-09 接受日期: 2006-12-01
Correlations of serum nitric oxide, interleukin-6, interleukin-10 and tumor necrosis factor levels with the prognosis of patients with liver cirrhosis
Qun Sun, Qiang Zhang, Jin-Shui Zhu, Wei Chen, Ni-Wei Chen
Qun Sun, Qiang Zhang, Jin-Shui Zhu, Wei Chen, Ni-Wei Chen,Department of Gastroenterology, the Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
Correspondence to:Jin-Shui Zhu, Department of Gastroenterology, the Sixth People’s Hospital of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. zhujs1803@hotmail.com
Received:2006-11-09 Accepted:2006-12-01
AbstractAIM:To study the roles of serum nitric oxide (NO), interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF) in the prognosis of patients with liver cirrhosis.
METHODS:Nitrate reductase assay and double-antibody sandwich enzyme-linked immunosorbent assay were used to examine the serum levels of NO, IL-6, IL-10 and TNF in 56 patients with liver cirrhosis before and after treatment, and 30 healthy individuals served as controls.
RESULTS:High levels of NO, IL-6, and TNF and low level of IL-10 were observed in patients with cirrhosis. After treatment, the serum levels of NO (129.21 ± 27.32 mmol/L vs 92.18 ± 25.68 mmol/L, P < 0.05), IL-6 (198.5 ± 23.2 mg/L vs 147.0 ± 19.1 mg/L, P < 0.05), and TNF (179.2 ± 23.5 pg/dL vs 121.4 ± 17.5 pg/dL, P < 0.05) were significantly elevated while the level of IL-10 (33.4 ± 7.2 mg/L vs 51.6 ± 18.5 mg/L, P < 0.05) was markedly decreased in patients with aggravated hepatic function as compared with those before therapy. However, the levels of NO (58.63 ± 12.25 mmol/L vs 94.36 ± 23.45 mmol/L, P < 0.05), IL-6 (90.3 ± 12.7 mg/L vs 148.5 ± 15.8 mg/L, P < 0.05) and TNF (78.2 ± 14.3 pg/dL vs 124.9 ± 20.1 pg/dL, P < 0.05) were decreased while the level of IL-10 (89.3 ± 18.9 mg/L vs 48.8 ± 9.5 mg/L, P < 0.05) was elevated in patients with improved hepatic function after treatment in comparison with those before treatment.
CONCLUSION: The serum levels of NO, IL-6, IL-10 and TNF are correlated with the prognosis of patients with liver cirrhosis.
Key Words: Liver cirrhosis; Nitric Oxide; Interleukin-6; Interleukin-10; Tumor necrosis factor; Prognosis
Sun Q, Zhang Q, Zhu JS, Chen W, Chen NW. Correlations of serum nitric oxide, interleukin-6, interleukin-10 and tumor necrosis factor levels with the prognosis of patients with liver cirrhosis.Shijie Huaren Xiaohua Zazhi 2007;15(6):659-662
摘要目的: 探讨血清一氧化氮(NO)、IL-6、IL-10、肿瘤坏死因子(TNF)水平与肝硬化患者预后之间的关系.
方法: 采用硝酸还原酶法、ELISA法、双抗体夹心酶联免疫分析法分别测定30例健康对照者和56例肝硬化患者治疗前后的血清NO, IL-6, IL-10及TNF水平 ......
孙群, 张强, 朱金水, 陈玮, 陈尼维, 上海交通大学附属第六人民医院消化科 上海市 200233
通讯作者: 朱金水, 200233, 上海市宜山路600号, 上海交通大学附属第六人民医院消化科. zhujs1803@hotmail.com
电话: 021-64369181-8969 传真: 0021-64837019
收稿日期: 2006-11-09 接受日期: 2006-12-01
Correlations of serum nitric oxide, interleukin-6, interleukin-10 and tumor necrosis factor levels with the prognosis of patients with liver cirrhosis
Qun Sun, Qiang Zhang, Jin-Shui Zhu, Wei Chen, Ni-Wei Chen
Qun Sun, Qiang Zhang, Jin-Shui Zhu, Wei Chen, Ni-Wei Chen,Department of Gastroenterology, the Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
Correspondence to:Jin-Shui Zhu, Department of Gastroenterology, the Sixth People’s Hospital of Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China. zhujs1803@hotmail.com
Received:2006-11-09 Accepted:2006-12-01
AbstractAIM:To study the roles of serum nitric oxide (NO), interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF) in the prognosis of patients with liver cirrhosis.
METHODS:Nitrate reductase assay and double-antibody sandwich enzyme-linked immunosorbent assay were used to examine the serum levels of NO, IL-6, IL-10 and TNF in 56 patients with liver cirrhosis before and after treatment, and 30 healthy individuals served as controls.
RESULTS:High levels of NO, IL-6, and TNF and low level of IL-10 were observed in patients with cirrhosis. After treatment, the serum levels of NO (129.21 ± 27.32 mmol/L vs 92.18 ± 25.68 mmol/L, P < 0.05), IL-6 (198.5 ± 23.2 mg/L vs 147.0 ± 19.1 mg/L, P < 0.05), and TNF (179.2 ± 23.5 pg/dL vs 121.4 ± 17.5 pg/dL, P < 0.05) were significantly elevated while the level of IL-10 (33.4 ± 7.2 mg/L vs 51.6 ± 18.5 mg/L, P < 0.05) was markedly decreased in patients with aggravated hepatic function as compared with those before therapy. However, the levels of NO (58.63 ± 12.25 mmol/L vs 94.36 ± 23.45 mmol/L, P < 0.05), IL-6 (90.3 ± 12.7 mg/L vs 148.5 ± 15.8 mg/L, P < 0.05) and TNF (78.2 ± 14.3 pg/dL vs 124.9 ± 20.1 pg/dL, P < 0.05) were decreased while the level of IL-10 (89.3 ± 18.9 mg/L vs 48.8 ± 9.5 mg/L, P < 0.05) was elevated in patients with improved hepatic function after treatment in comparison with those before treatment.
CONCLUSION: The serum levels of NO, IL-6, IL-10 and TNF are correlated with the prognosis of patients with liver cirrhosis.
Key Words: Liver cirrhosis; Nitric Oxide; Interleukin-6; Interleukin-10; Tumor necrosis factor; Prognosis
Sun Q, Zhang Q, Zhu JS, Chen W, Chen NW. Correlations of serum nitric oxide, interleukin-6, interleukin-10 and tumor necrosis factor levels with the prognosis of patients with liver cirrhosis.Shijie Huaren Xiaohua Zazhi 2007;15(6):659-662
摘要目的: 探讨血清一氧化氮(NO)、IL-6、IL-10、肿瘤坏死因子(TNF)水平与肝硬化患者预后之间的关系.
方法: 采用硝酸还原酶法、ELISA法、双抗体夹心酶联免疫分析法分别测定30例健康对照者和56例肝硬化患者治疗前后的血清NO, IL-6, IL-10及TNF水平 ......
您现在查看是摘要介绍页，详见PDF附件(1kb)。